ArticleNature2025
Fluctuating DNA methylation tracks cancer evolution at clinical scale.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Molecular predictors of minimal residual disease in newly diagnosed multiple myeloma treated with quadruplet therapy.Nature medicine · 2026Article
- Differences between mitotically old and young endometrial tumors.The Journal of pathology · 2026Article
- The Evolution of Polyclonal Competition in Aging Hematopoiesis.Cancer discovery · 2026Article
- Sellar region neurocytomas exhibit a CIMP and neuroendocrine-like epigenetic signature distinct from other intra-axial neurocytomas.Acta neuropathologica · 2026Article
- Charting intratumor heterogeneity from bench to bedside.Nature cancer · 2026Review
- Fluctuating DNA methylation sites encode colorectal tumour growth history.bioRxiv : the preprint server for biology · 2026Article
- Conception-calibrated male pediatric tumor mitotic clocks.Communications biology · 2026Article
- Germline regulation of tumor evolutionary dynamics shapes multiple myeloma progression.bioRxiv : the preprint server for biology · 2026Article
- Charting single-cell lineages with synthetic and natural barcodes.Nature reviews. Genetics · 2026Review
- PHYFUM: Phylogenetic Reconstruction of Normal and Pre-malignant Tissue Evolution Using Fluctuating Methylation.bioRxiv : the preprint server for biology · 2026Article
- Expanding role of cell-free DNA for the early diagnosis and monitoring of pulmonary diseases.Chinese medical journal · 2026Review
- Aggressive Neuroblastomas Start Growing after Infancy.bioRxiv : the preprint server for biology · 2026Article
- The pioneering work of Howard Cedar and his team in unraveling the roles DNA methylation plays in regulating genome function.Frontiers in epigenetics and epigenomics · 2026Article
- Epigenetic reprogramming as the nexus of cancer stemness and therapy resistance: implications for biomarker discovery.Discover oncology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Calum Gabbutt *Centre for Evolution and Cancer, Institute of Cancer Research, London, UK. c.gabbutt@imperial.ac.uk.ORCID 0000-0003-1946-4780
Martí Duran-Ferrer *Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.ORCID 0000-0003-1666-5819
Heather E GrantCentre for Evolution and Cancer, Institute of Cancer Research, London, UK.ORCID 0000-0001-9500-1644
Diego MalloArizona Cancer Evolution Center, Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, AZ, USA.ORCID 0000-0002-9046-8859
Ferran NadeuFundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.ORCID 0000-0003-2910-9440
Jacob HousehamCentre for Evolution and Cancer, Institute of Cancer Research, London, UK.ORCID 0000-0003-3199-336X
Neus VillamorFundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.ORCID 0000-0001-6538-4111
Madlen MüllerCentro Nacional de Analisis Genomico (CNAG), Barcelona, Spain.ORCID 0000-0002-1381-7517
Simon HeathCentro Nacional de Analisis Genomico (CNAG), Barcelona, Spain.
Emanuele RaineriCentro Nacional de Analisis Genomico (CNAG), Barcelona, Spain.
Olga KraliDepartment of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-6436-9531
Jessica NordlundDepartment of Medical Sciences, Molecular Precision Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID 0000-0001-8699-9959
Thorsten ZenzDepartment of Medical Oncology and Hematology, University Hospital and University of Zürich, Zurich, Switzerland.ORCID 0000-0001-7890-9845
Ivo G GutCentro Nacional de Analisis Genomico (CNAG), Barcelona, Spain.ORCID 0000-0001-7219-632X
Elias CampoFundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.ORCID 0000-0001-9850-9793
Armando Lopez-GuillermoFundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.
Jude FitzgibbonCentre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Chris P BarnesDepartment of Cell and Developmental Biology, University College London, London, UK.ORCID 0000-0002-9459-1395
Darryl ShibataDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-4567-1639
José I Martin-SuberoFundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain. imartins@recerca.clinic.cat.ORCID 0000-0001-8809-5195
Trevor A GrahamCentre for Evolution and Cancer, Institute of Cancer Research, London, UK. trevor.graham@icr.ac.uk.ORCID 0000-0001-9582-1597
Funding
The Role of the Microbiome in Cancer Suppression and Susceptibility Across SpeciesU54CA217376 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI MALEY, CARLO · 2018 to 2022
$8.6MModeling Neoplastic Progression in Barrett's Esophagus - Renewal -2R01CA140657 · NCI · WISTAR INSTITUTE · PI Carlo Maley · 2009 to 2026
$5.0MAccelerator award Cancer Research UK/AIRC/AECC joint funder-partnershipBBSRC London Interdisciplinary Doctoral ProgrammeNCI NIH HHS R01 CA140657NCI NIH HHS U54 CA217376
Abstract
Cancer development and response to treatment are evolutionary processes
Indexed as
DNA MethylationEvolution, MolecularNeoplasmsClone CellsFemaleHumansLeukemia, Lymphocytic, Chronic, B-CellMalePhylogenyPrognosis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.