Trial reportJournal of perinatology : official journal of the California Perinatal Association2025
Acute kidney injury and subsequent risk of late-onset infection among extremely low gestational age newborns.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A Pathophysiological Approach for Early Detection and Prevention of AKI in the NICU.American journal of perinatology · 2026Review
- Examining the role of biologic sex on kidney outcomes in preterm neonates: A secondary analysis of the PENUT/REPAIReD study.Pediatric nephrology (Berlin, Germany) · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveDetermine whether acute kidney injury (AKI) is associated with subsequent late-onset infection (LOI) among extremely low gestational age newborns (ELGAN). STUDY
designSecondary analysis of participants in the Preterm Erythropoietin for Neuroprotection Trial. Infants surviving ≥7 days with sufficient serum creatinine data were included. The primary outcome was any LOI, starting ≥72 h after AKI. Time-varying Cox proportional hazards modeling estimated adjusted hazard ratios of AKI and LOI.
results332/872 (38%) study infants experienced AKI. 552/872 (63%) experienced LOI. 336/552 (60.9%) of late-onset infections were culture-positive, and 216/552 (39.1%) were culture-negative. After adjusting for gestational age, sex, postnatal steroids, vancomycin/gentamicin receipt ≥72 h, birthweight, and 5-min APGAR, any AKI was associated with 1.47x increased hazard of subsequent LOI (adjusted HR: 1.47; 95% CI: 1.15-1.87).
conclusionPrior AKI increased hazard of subsequent LOI in a large cohort of ELGANs. Clinicians may anticipate higher risk of infectious complications after AKI.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.