Evidence map›Paper›PMID 40931033›Full record

ArticleEye (London, England)2025

Peripheral vitreoretinal abnormality and its correlation with malignant glaucoma in nanophthalmos with secondary angle closure glaucoma.

Yan Gao, Yan Shi, Xiaowei Yu, Hongyu Zhong, Feng Mei, Xueting Pei, Shuhua Wang, Zhigang Fan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yan Gao *Beijing Tongren Eye Center Research Ward, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Ophthalmology & Visual Sciences Key Laboratory, Capital Medical University, Beijing, China.
Yan Shi *Beijing Tongren Eye Center Research Ward, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Ophthalmology & Visual Sciences Key Laboratory, Capital Medical University, Beijing, China.
Xiaowei YuBeijing Tongren Eye Center Research Ward, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Ophthalmology & Visual Sciences Key Laboratory, Capital Medical University, Beijing, China.
Hongyu ZhongBeijing Tongren Eye Center Research Ward, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Ophthalmology & Visual Sciences Key Laboratory, Capital Medical University, Beijing, China.
Feng MeiBeijing Tongren Eye Center Research Ward, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Ophthalmology & Visual Sciences Key Laboratory, Capital Medical University, Beijing, China.
Xueting PeiBeijing Tongren Eye Center Research Ward, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Ophthalmology & Visual Sciences Key Laboratory, Capital Medical University, Beijing, China.
Shuhua WangBeijing Tongren Eye Center Research Ward, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Ophthalmology & Visual Sciences Key Laboratory, Capital Medical University, Beijing, China.
Zhigang FanBeijing Tongren Eye Center Research Ward, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Ophthalmology & Visual Sciences Key Laboratory, Capital Medical University, Beijing, China. fanzhigang@mail.ccmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the peripheral vitreoretinal abnormality (PVA) and its correlation with the risk of malignant glaucoma (MG) in nanophthalmos with secondary angle closure glaucoma (NSACG).

methodsThis prospective case series included 47 NSACG eyes with axial length (AL) < 21 mm from 25 patients. PVA was defined as a hyperreflective echo at the peripheral vitreoretinal region under ultrasound biomicroscopy (UBM). Eyes were categorised into two groups based on the presence (PVA group) or absence (NPVA group) of PVA. AL, lens thickness (LT), radius of corneal curvature (K1: flat, K2: steep), and corneal cylinder degree (CYL) were measured by IOL-Master. Anterior chamber depth (ACD), lens vault (LV), corneal limbus thickness (CLT), trabecular-ciliary processes distance (TCPD) and angle (TCPA), and peripheral iris thickness (PIT) were measured by UBM. MG incidence was recorded during a minimum 2-year follow-up.

resultsPVA was detected in 29 eyes(62%) from 16 patients (64%). PVA eyes had shorter AL, TCPD, TCPA and larger PIT, LT, LV, CLT, K1, K2 compared to NPVA eyes (all P < 0.05). Thirteen eyes (45%) in the PVA group developed MG postoperatively vs none in the NPVA group (P < 0.05). Logistic regression analysis, adjusted for AL, identified older age, greater angle occlusion, larger K2, higher CYL, thicker LT and CLT as significant risk factors for MG (all P < 0.05).

conclusionsWe first reported PVA under UBM in NSACG eyes, which may partially explain their anatomical predisposition to advanced ACG and MG, and aid in the management of these eyes.

Indexed as

Glaucoma, Angle-ClosureMicrophthalmosAdultAgedAxial Length, EyeFemaleHumansIntraocular PressureMaleMicroscopy, AcousticMiddle AgedProspective StudiesRisk Factors

Identifiers

PMID40931033
PMCPMC12583526

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.