ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
Prefrontal Network Mechanisms of Psychiatric Deep Brain Stimulation.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Real-time Bayesian optimization of deep brain stimulation for personalized cognitive control enhancement.bioRxiv : the preprint server for biology · 2025Article
- Computational Properties of the Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Deep brain stimulation (DBS) is an emerging treatment for otherwise treatment-refractory psychiatric disorders. It can produce remarkable clinical results in expert hands, but has not fared as well in controlled, multisite trials. That difficulty with scaling up arises in part because DBS' mechanisms are poorly understood, meaning that it is difficult to objectively identify patients likely to respond and/or to customize stimulation to match individual patients' needs. In the first part of this review, we overview converging anatomic and physiological evidence that psychiatric DBS acts by modulating distributed networks centered on the prefrontal cortex (PFC). We discuss potential physiological mechanisms of that modulation, including mixed excitatory/inhibitory effects, changes in local field potential oscillations, and neuroplastic changes. A major challenge is that mechanistic data from humans are limited and sometimes contradictory, in part because these studies can only be conducted at low
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.