Evidence map›Paper›PMID 40930872›Full record

Trial reportBritish journal of anaesthesia2025

Association of intraoperative end-tidal CO

Prashant Nasa, David M P van Meenen, Frederique Paulus, Carlos Ferrando, Thomas Bluth, Marcelo Gama de Abreu, Lorenzo Ball, Sebastiaan M Bossers, Patrick Schober, Marcus J Schultz and 7 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02148692 nacompletednot on this map

Protective Ventilation With Higher Versus Lower PEEP During General Anesthesia for Surgery in Obese Patients

TypeinterventionalSponsorTechnische Universität DresdenRan2014 to 2018Enrolled2,013ConditionsMorbid Obesity, Surgery, General AnesthesiaArmsHigher PEEP, Lower PEEP
NCT05550181 completednot on this map

Associations of Intraoperative Hypocapnia With Patient Demographics, Ventilation Characteristics and Outcomes--Statistical Analysis Plan for an Individual Patient Data Analysis of PROVHILO and PROBESE

TypeobservationalSponsorNMC Specialty HospitalRan2022 to 2023Enrolled2,793ConditionsMechanical Ventilation Complication, Surgery, Pulmonary Complication, Intraoperative ComplicationsArmsintraoperative mechanical ventilation with hypocapnia (etCO2 < 35 mm Hg)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Intraoperative ventilation settings in Germany: an observational multicentre cross-sectional study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Prashant NasaDepartment of Anaesthesia and Critical Care Medicine, New Cross Hospital, The Royal Wolverhampton NHS Trust, Wolverhampton, UK; Department of Intensive Care, Amsterdam University Medical Centers, location 'AMC', Amsterdam, The Netherlands. Electronic address: dr.prashantnasa@hotmail.com.
David M P van MeenenDepartment of Intensive Care, Amsterdam University Medical Centers, location 'AMC', Amsterdam, The Netherlands; Department of Anaesthesiology, Amsterdam University Medical Centers, location 'AMC', Amsterdam, The Netherlands; Department of Intensive Care & Laboratory of Experimental Intensive Care and Anaesthesiology (L·E·I·C·A), Amsterdam University Medical Centers, location 'AMC', Amsterdam, The Netherlands.
Frederique PaulusDepartment of Intensive Care, Amsterdam University Medical Centers, location 'AMC', Amsterdam, The Netherlands.
Carlos FerrandoDepartment of Anaesthesiology and Critical Care, Hospital Clinic de Barcelona, Barcelona, Spain; CIBER of Respiratory Disease, Carlos III Health Institute, Madrid, Spain.
Thomas BluthPulmonary Engineering Group, Department of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Marcelo Gama de AbreuPulmonary Engineering Group, Department of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany; Departments of Intensive Care and Resuscitation and Outcomes Research Department of Cardiothoracic Anaesthesiology, Cleveland Clinic, Cleveland, OH, USA.
Lorenzo BallDepartment of Surgical Sciences and Integrated Diagnostics (DISC), IRCCS San Martino Policlinico Hospital, University of Genoa, Genoa, Italy.
Sebastiaan M BossersDepartment of Anaesthesiology, Amsterdam University Medical Centers, location 'VUmc', Amsterdam, The Netherlands.
Patrick SchoberDepartment of Anaesthesiology, Amsterdam University Medical Centers, location 'VUmc', Amsterdam, The Netherlands; Helicopter Emergency Medical Service Lifeliner 1, Amsterdam, The Netherlands.
Marcus J SchultzDepartment of Intensive Care, Amsterdam University Medical Centers, location 'AMC', Amsterdam, The Netherlands; Department of Intensive Care & Laboratory of Experimental Intensive Care and Anaesthesiology (L·E·I·C·A), Amsterdam University Medical Centers, location 'AMC', Amsterdam, The Netherlands; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Bangkok, Thailand; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Department of Anaesthesia, General Intensive Care and Pain Management, Division of Cardiothoracic and Vascular Anaesthesia & Critical Care Medicine, Medical University of Vienna, Vienna, Austria.
Ary Serpa NetoAustralian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia; Department of Intensive Care, Melbourne Medical School, University of Melbourne, Austin Hospital, Melbourne, Australia; Department of Critical Care, Melbourne Medical School, University of Melbourne, Austin Hospital, Melbourne, Australia; Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Sabrine N T HemmesDepartment of Anaesthesiology, Amsterdam University Medical Centers, location 'AMC', Amsterdam, The Netherlands; Department of Anaesthesiology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
REPEAT
PROVHILO
PROBESE
investigators of the PROVE network
ESAIC CTN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe relationship between intraoperative end-tidal CO

methodsWe re-analysed individual participant data comparing high or low positive end-expiratory pressure with low tidal volume intraoperative ventilation using a merged database derived from two randomised trials in non-obese (PROVHILO: ISRCTN70332574) and obese (PROBESE: NCT02148692) patients. The exposure of interest was low etCO

resultsOf 2793 participants, 891 (29.4%; 52% female) had low etCO

conclusionsLow etCO CLINICAL

trial registrationNCT05550181.

Indexed as

Carbon DioxidePostoperative ComplicationsAdultAgedAnesthesia, GeneralFemaleHumansLung DiseasesMaleMiddle AgedPositive-Pressure RespirationRandomized Controlled Trials as TopicTidal VolumeTreatment OutcomeCarbon Dioxideanaesthesiacarbon dioxideend-tidal CO(2)etCO(2)intraoperative ventilationinvasive ventilationpostoperative pulmonary complicationsPPCs

Identifiers

PMID40930872
PMCPMC12799414

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.