Evidence map›Paper›PMID 40930830›Full record

ArticleInternal medicine (Tokyo, Japan)2026

C3 p.Asp1115Asn Variant-associated Atypical Hemolytic Uremic Syndrome with Spontaneous Remission Triggered by Influenza and COVID-19.

Yudai Fujino, Hinako Hanada, Tomoaki Takata, Kana Kageyama, Sosuke Taniguchi, Yukari Mae, Shotaro Hoi, Takuji Iyama, Akinori Watanabe, Sho Sasaki and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yudai FujinoDepartment of Gastroenterology and Nephrology, Tottori University Hospital, Japan.
Hinako HanadaDepartment of Gastroenterology and Nephrology, Tottori University Hospital, Japan.
Tomoaki TakataDepartment of Gastroenterology and Nephrology, Tottori University Hospital, Japan.
Kana KageyamaDepartment of Gastroenterology and Nephrology, Tottori University Hospital, Japan.
Sosuke TaniguchiDepartment of Gastroenterology and Nephrology, Tottori University Hospital, Japan.
Yukari MaeDepartment of Gastroenterology and Nephrology, Tottori University Hospital, Japan.
Shotaro HoiDepartment of Gastroenterology and Nephrology, Tottori University Hospital, Japan.
Takuji IyamaDepartment of Gastroenterology and Nephrology, Tottori University Hospital, Japan.
Akinori WatanabeDepartment of Nephrology and Hypertension, Sumitomo Hospital, Japan.
Sho SasakiDepartment of Nephrology and Hypertension, Sumitomo Hospital, Japan.
Shinichiro TsunodaDepartment of Nephrology and Hypertension, Sumitomo Hospital, Japan.
Atsuyuki MorishimaDepartment of Nephrology and Hypertension, Sumitomo Hospital, Japan.
Hajime IsomotoDepartment of Gastroenterology and Nephrology, Tottori University Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical manifestations of atypical hemolytic uremic syndrome (aHUS) vary depending on the genetic background. A 19-year-old man with the C3 p.Asp1115Asn variant experienced 2 episodes of recurrent aHUS following respiratory tract infections caused by influenza and coronavirus disease 2019 (COVID-19). The patient's symptoms spontaneously remitted without plasma exchange or eculizumab treatment in both episodes. This is the first case of aHUS in the p.Asp1115Asn variant in Japan, highlighting that influenza and COVID-19 infections can be an environmental trigger to develop aHUS in patients harboring the C3 p.Asp1115Asn mutation and that aHUS associated with this mutation may not always be severe.

Indexed as

Atypical Hemolytic Uremic SyndromeComplement C3COVID-19Influenza, HumanHumansMaleMutationRemission, SpontaneousSARS-CoV-2Young AdultC3 protein, humanComplement C3aHUSatypical hemolytic uremic syndromecomplementCOVID-19influenzathrombotic microangiopathy

Identifiers

PMID40930830
PMCPMC13175673

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.