Evidence map›Paper›PMID 40930828›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Adult-onset Vitamin K-dependent Coagulation Factor Deficiency of Unidentified Etiology.

Yui Araki, Miyuki Ookura, Naoko Ida, Hiroki Tsukamoto, Takashi Shinoda, Koji Morinaga, Naoko Hosono, Yasukazu Kawai, Takahiro Yamauchi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yui ArakiDepartment of Hematology and Oncology, Fukui Prefectural Hospital, Japan.
Miyuki OokuraDepartment of Hematology and Oncology, University of Fukui Hospital, Japan.
Naoko IdaDepartment of Hematology and Oncology, University of Fukui Hospital, Japan.
Hiroki TsukamotoDepartment of Hematology and Oncology, Fukui Prefectural Hospital, Japan.
Takashi ShinodaDepartment of Hematology and Oncology, Fukui Prefectural Hospital, Japan.
Koji MorinagaDepartment of Hematology and Oncology, Fukui Prefectural Hospital, Japan.
Naoko HosonoDepartment of Hematology and Oncology, University of Fukui Hospital, Japan.
Yasukazu KawaiDepartment of Hematology and Oncology, Fukui Prefectural Hospital, Japan.
Takahiro YamauchiDepartment of Hematology and Oncology, University of Fukui Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Symptoms of bleeding caused by vitamin K-dependent coagulation factor deficiency (VKCFD) are rare in adults. We present two Japanese cases of adult-onset VKCFD, in which the cause of vitamin K deficiency remains unknown despite comprehensive evaluation. Both patients showed markedly decreased levels of coagulation factors (F) VII, FIX, FX, FII, protein C, and protein S, along with elevated levels of protein induced by vitamin K absence/antagonist II. The clinical course in both cases ruled out congenital VKCFD. Based on these findings and a similar case in the relevant literature, we propose a new disease entity, idiopathic acquired VKCFD.

Indexed as

Vitamin K DeficiencyAdultAgedAge of OnsetBlood Coagulation FactorsFemaleHumansMaleMiddle AgedVitamin KBlood Coagulation FactorsVitamin Kacquired coagulopathyvitamin Kvitamin K-dependent coagulation factor deficiency

Identifiers

PMID40930828
PMCPMC13106790

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.