Evidence map›Paper›PMID 40930800›Full record

ArticleThe Journal of veterinary medical science2025

Acute toxicity of local anesthetics used for humans and other animals in the larvae of marine crustacean, red-clawed crab Chiromantes haematocheir.

Atsushi Nishikawa, Keito Tsunoda, Kaito Hatano, Yoshiaki Tabuchi, Tetsushi Hirano, Riku Izumi, Shion Oshima, Yukihiro Furusawa, Akihiro Sakatoku, Ajai K Srivastav and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Atsushi NishikawaNoto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Ishikawa, Japan.
Keito TsunodaNoto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Ishikawa, Japan.
Kaito HatanoNoto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Ishikawa, Japan.
Yoshiaki TabuchiLife Science Research Center, University of Toyama, Toyama, Japan.
Tetsushi HiranoLife Science Research Center, University of Toyama, Toyama, Japan.
Riku IzumiNoto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Ishikawa, Japan.
Shion OshimaNoto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Ishikawa, Japan.
Yukihiro FurusawaDepartment of Pharmaceutical Engineering, Faculty of Engineering, Toyama Prefectural University, Toyama, Japan.
Akihiro SakatokuSchool of Science, Academic Assembly, University of Toyama, Toyama, Japan.
Ajai K SrivastavDepartment of Zoology, D.D.U. Gorakhpur University, Gorakhpur, India.
Masato HondaBotanical Garden, Institute of Nature and Environmental Technology, Kanazawa University, Ishikawa, Japan.
Hajime MatsubaraNoto Center for Fisheries Science and Technology, Kanazawa University, Ishikawa, Japan.
Shouzo OgisoNoto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Ishikawa, Japan.
Marin TakasuNoto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Ishikawa, Japan.
Chun-Sang HongResearch Institute for Radiation Satellite, Gangneung-Wonju National University, Gangwon, Republic of Korea.
Jun HirayamaFaculty of Education, Bunkyo University, Saitama, Japan.
Atsuhiko HattoriDepartment of Sport and Wellness, College of Sport and Wellness, Rikkyo University, Saitama, Japan.
Nobuo SuzukiNoto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Ishikawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Local anesthetics such as lidocaine have been used in humans and other animals to perform surgical procedures, therapeutics, and experiments. Lidocaine discarded into the environment through industrial waste, human and animal excretion, and household waste has been detected in the aquatic environment. For example, lidocaine in rivers, lakes, and influent and effluent water has been detected at wastewater treatment plants (7 ng/L-2.06 μg/L), suggesting that this chemical substance influences aquatic animals. However, the toxic effects of lidocaine on marine organisms have not been investigated. This study examined the acute toxicity of local anesthetics (lidocaine and dibucaine) on the marine zoea larvae of red-clawed crabs, which feature a life cycle in which adults live on land and larvae live in the sea. Survival analysis of zoea larvae revealed that dibucaine was more toxic than lidocaine. The 50% effective concentrations (EC

Indexed as

Anesthetics, LocalBrachyuraLidocaineWater Pollutants, ChemicalAnimalsKidneyLarvaAnesthetics, LocalLidocaineWater Pollutants, Chemicallocal anestheticmarine crustaceanmelatonintoxicityzoea larva

Identifiers

PMID40930800
PMCPMC12604965

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.