SynthesisPhysiological reports2025
The renal baroreflex: A systematic review and meta-analysis in healthy and hypertensive animals.
Synthesis in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- The renal baroreflex: A systematic review and meta-analysis in healthy and hypertensive animals.Physiological reports · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The renal baroreflex describes the dose-dependent relation between renal pressure and renin release. Former studies have approximated this relation through animal experiments, but the exact shape of the response curve and its alteration by hypertension remain unclear. Therefore, we conducted a systematic review and meta-analysis on the renal baroreflex in healthy and hypertensive animals. Studies retrieved from Pubmed and Embase were screened according to predefined criteria. Data regarding study design and outcome data were extracted, and risk of bias was assessed. Dose-response meta-analysis was conducted on the relationship between renal blood pressure and renin release. Subgroup analyses were conducted for species, sex, outcome units, and experimental setup. From 1508 studies, 55 were included in the systematic review, and 30 in the meta-analysis. Risk of bias was high in most studies. Our meta-analysis shows that in healthy animals, renin decreases linearly with increasing renal blood pressure, reaching a plateau above a threshold pressure of 93 ± 2 mmHg. In hypertensive animals, the linear slope is diminished, the threshold is comparable, and the plateau level is slightly decreased as compared to healthy animals. Despite some limitations, our findings suggest that high blood pressure in hypertensive animals blunts the renal baroreflex by resetting and suppression of the renin response to changes in blood pressure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.