ArticleBMJ health & care informatics2025
Wearable device-measured circadian rest-activity rhythm with mortality risk in patients with cancer.
Article in BMJ health & care informatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Chronotherapy in Oncology: Aligning Cancer Treatment with Biological Time.Journal of personalized medicine · 2026Review
- Chronotherapy in Hematological Malignancies: Evaluating the Rationale and Evidence.Pharmacology research & perspectives · 2026Review
- Circadian rhythms and lung cancer biology and immunotherapy: Emerging opportunities and challenges.Chinese medical journal pulmonary and critical care medicine · 2026Review
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe objectives were to examine the associations between accelerometer-measured circadian rest-activity rhythm (CRAR), the most prominent circadian rhythm in humans and the risk of mortality from all-cause, cancer and cardiovascular disease (CVD) in patients with cancer.
methods7456 cancer participants from the UK Biobank were included. All participants wore accelerometers from 2013 to 2015 and were followed up until 24 January 2024, with a median follow-up of 9.00 years. The multidimensional parameters of the CRAR were calculated using the 7-day accelerometer data collected under free-living conditions. Cox proportional hazard models were used to evaluate the associations between CRAR and all-cause, cancer and CVD mortality.
resultsAmong 7456 cancer patients (mean age: 65.7±6.87 years; 58.85% women) aged 44-79 years, 934 (12.5%) deaths occurred over 9.00 years (64 525 person-years). CRAR disruptions, including low amplitude, low mesor and high fragmentation, were significantly associated with an increased risk of all-cause mortality (adjusted HR range, 1.30-2.00), cancer (adjusted HR range, 1.46-1.83) and CVD mortality (adjusted HR range, 1.73-2.66) in patients with cancer. DISCUSSION: These associations were robust across various cancer types. In addition, CRAR disruptions, particularly low amplitude, exceeded multiple traditional risk factors such as poor sleep, smoking, alcohol consumption, obesity and unhealthy diet in predicting mortality.
conclusionCRAR parameters may serve as novel and robust predictors of mortality in patients with cancer.
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