Evidence map›Paper›PMID 40930455›Full record

ArticleToxicology2025

Differential effects of mercury compounds on mutagenicity, genotoxicity and repair of UV-DNA damage.

Anna Cyran, Giorgiana Madalina Ursu, Casey Krawic, Anatoly Zhitkovich

Abstract read
In one paragraph

Article in Toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Duration-dependent mild heat stress attenuates mercury-induced Neuroreproductive and oxidative toxicity in Drosophila melanogaster via hormetic mechanisms.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anna CyranBrown University, Department of Pathology and Laboratory Medicine, Providence, RI 02903, USA.
Giorgiana Madalina UrsuBrown University, Department of Pathology and Laboratory Medicine, Providence, RI 02903, USA.
Casey KrawicBrown University, Department of Pathology and Laboratory Medicine, Providence, RI 02903, USA.
Anatoly ZhitkovichBrown University, Department of Pathology and Laboratory Medicine, Providence, RI 02903, USA. Electronic address: anatoly_zhitkovich@brown.edu.

Funding

Indirect Genotoxicity in Metal CarcinogenesisR01ES031002 · NIEHS · BROWN UNIVERSITY · PI ZHITKOVICH, ANATOLY · 2020 to 2024
$1.8M
Nickel and toxic topoisomerase I productsR01ES031979 · NIEHS · BROWN UNIVERSITY · PI ZHITKOVICH, ANATOLY · 2021 to 2025
$1.8M
NIEHS NIH HHS R01 ES031002NIEHS NIH HHS R01 ES031979
6 · The paper itself

Abstract

Mercury (Hg) is a global contaminant that is present in human diet as methylmercury (MeHg). Recent studies linked MeHg exposure with high risks of skin cancers. It is unknown whether MeHg is directly genotoxic in skin cells or able to enhance mutagenic effects of UV radiation. We examined mutagenicity and genotoxicity of MeHg and its metabolite inorganic Hg

Indexed as

DNA DamageDNA RepairMercury CompoundsMethylmercury CompoundsMutagensUltraviolet RaysAnimalsCHO CellsCricetinaeCricetulusHumansKeratinocytesMicronucleus TestsMutagenicity TestsPyrimidine DimersMercury CompoundsMethylmercury CompoundsMutagensPyrimidine DimersGenotoxicityMercuryMethylmercuryMutagenesisNucleotide excision repairUV-DNA damage

Identifiers

PMID40930455
PMCPMC12477637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.