Evidence map›Paper›PMID 40930373›Full record

ArticleBiological psychiatry2026

RNA in Plasma Extracellular Vesicles of Adolescent Rhesus Macaques Reveals Immune, Bioenergetic, and Microbial Imprints of Early-Life Adversity: An Exploratory Analysis.

Laura Korobkova, Matthew E Thornton, Matthew A Collin, Elyse L Morin, Hadj Aoued, Soma Sannigrahi, Nabeel Bhinderwala, Kristie M Garza, Erin R Siebert, Hasse Walum and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Laura KorobkovaNeuroscience Graduate Program, University of Southern California, Los Angeles, California; Developmental Neuroscience and Neurogenetics Program, The Saban Research Institute, Los Angeles, California.
Matthew E ThorntonDivision of Maternal-Fetal Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California.
Matthew A CollinQiagen Sciences, Frederick, Maryland.
Elyse L MorinEmory National Primate Research Center, Atlanta, Georgia; Department of Psychiatry & Behavioral Sciences, Emory University, Atlanta, Georgia.
Hadj AouedEmory National Primate Research Center, Atlanta, Georgia.
Soma SannigrahiEmory National Primate Research Center, Atlanta, Georgia.
Nabeel BhinderwalaDevelopmental Neuroscience and Neurogenetics Program, The Saban Research Institute, Los Angeles, California.
Kristie M GarzaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia.
Erin R SiebertEmory National Primate Research Center, Atlanta, Georgia.
Hasse WalumEmory National Primate Research Center, Atlanta, Georgia.
Ryan P CabeenUSC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California.
Brendan H GrubbsDivision of Maternal-Fetal Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California.
Mar M SanchezEmory National Primate Research Center, Atlanta, Georgia; Department of Psychiatry & Behavioral Sciences, Emory University, Atlanta, Georgia.
Brian G DiasDevelopmental Neuroscience and Neurogenetics Program, The Saban Research Institute, Los Angeles, California; Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto, Ontario, Canada; Division of Endocrinology, Children's Hospital Los Angeles, Los Angeles, California; Department of Pediatrics, Keck School of Medicine of University of Southern California, Los Angeles, California. Electronic address: bdias@chla.usc.edu.

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Project 3: The neurobiology of adverse early care in rhesus infants....P50MH078105 · NIMH · UNIVERSITY OF MINNESOTA · PI GUNNAR, MEGAN R · 2009 to 2013
$9.9M
Early Life Stress, Chronic Drug Use and Neuroplasticity in Nonhuman Primate Models of Cocaine Abuse: Relevance to Treatment StrategiesR01DA052909 · NIDA · EMORY UNIVERSITY · PI Michael A Nader, MAR M SANCHEZ · 2021 to 2026
$4.9M
Early life stress and adolescent cocaine abuse: neurobiological vulnerabilitiesR01DA038588 · NIDA · EMORY UNIVERSITY · PI SANCHEZ, MAR M · 2014 to 2020
$3.5M
Understanding cellular and molecular legacies of paternal stressR56MH128427 · NIMH · CHILDREN'S HOSPITAL OF LOS ANGELES · PI DIAS, BRIAN GEORGE · 2022 to 2023
$1.4M
NIDA NIH HHS R01 DA038588NIDA NIH HHS R01 DA052909NIH HHS P51 OD011132NIMH NIH HHS P50 MH078105NIMH NIH HHS R56 MH128427
6 · The paper itself

Abstract

backgroundExposure to early-life adversity (ELA), including childhood maltreatment, is one of the most significant risk factors for the emergence of psychosomatic disorders in adolescence and adulthood. Most investigations into biological processes that have been perturbed by ELA have profiled DNA methylation in whole blood and coalesced around perturbations of immunobiology being centrally insulted by ELA.

methodsTo identify novel molecular signatures that are enduringly perturbed by childhood maltreatment, we isolated circulating extracellular vesicles (EVs) from plasma collected from adolescent rhesus macaques that had either experienced nurturing maternal care (n = 7; 3 female, 4 male) or maltreatment in infancy (n = 6; 3 female, 3 male). Next, we profiled the RNA found in these EVs.

resultsRNA associated with genes related to translation, ATP (adenosine triphosphate) synthesis, mitochondrial function, and immune response were downregulated in circulating EVs collected from adolescent macaques that had experienced maltreatment during infancy, while those involved in ion transport, metabolism, and cell differentiation were upregulated in these EVs. Additionally, a significant proportion of EV RNA aligned to the microbiome and maltreatment during infancy altered the diversity of microbiome-associated RNA signatures found in EVs.

conclusionsOur findings provide evidence that alterations in RNA associated with immune function, cellular energetics, and the microbiome in circulating EVs may serve as enduring biomarkers of prior exposure to ELA. As a corollary, perturbations of these RNA profiles may offer novel molecular insight into how biology can remain altered long after the shadow of ELA has passed.

Indexed as

Extracellular VesiclesRNAStress, PsychologicalAnimalsEnergy MetabolismFemaleMacaca mulattaMaleMicrobiotaRNAAdolescenceExtracellular vesiclesInfant maltreatmentMicrobiomeNonhuman primateRNA

Identifiers

PMID40930373
PMCPMC12911324

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.