Evidence map›Paper›PMID 40930064›Full record

ArticleStem cell reports2025

Distinct roles of TET-mediated cytosine oxidation in neural stem cell fate decisions.

Oren Ram

Abstract read
In one paragraph

Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Oren RamDepartment of Biological Chemistry, Alexander Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel. Electronic address: oren.ram@mail.huji.ac.il.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ten-eleven translocation (TET) enzymes regulate neural stem cell development via distinct cytosine oxidation steps. This study, by Ebert et al. reveals that hydroxymethylation is crucial for neurogenesis, while formylation and carboxylation drive gliogenesis, offering insights into TET biology and therapeutic potential in neurodevelopmental and neurodegenerative disorders.

Indexed as

CytosineDNA-Binding ProteinsNeural Stem CellsProto-Oncogene ProteinsAnimalsCell DifferentiationCell LineageHumansNeurogenesisOxidation-ReductionCytosineDNA-Binding ProteinsProto-Oncogene Proteins

Identifiers

PMID40930064
PMCPMC12447316

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.