Evidence map›Paper›PMID 40930062›Full record

ArticleStem cell reports2025

The KAP1 chromatin regulator and Paupar long non-coding RNA control subventricular zone neural stem cell maintenance and neurogenesis.

Farah Alammari, Jemima Becker, Bin Sun, Anna Hoerder-Suabedissen, Keith W Vance, Francis G Szele

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In one paragraph

Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Farah AlammariDepartment of Physiology, Anatomy and Genetics, University of Oxford, OX1 3PT Oxford, UK; Department of Blood and Cancer Research, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Clinical Laboratory Sciences Department, College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. Electronic address: farah.alammari@gmail.com.
Jemima BeckerDepartment of Physiology, Anatomy and Genetics, University of Oxford, OX1 3PT Oxford, UK.
Bin SunDepartment of Physiology, Anatomy and Genetics, University of Oxford, OX1 3PT Oxford, UK.
Anna Hoerder-SuabedissenDepartment of Physiology, Anatomy and Genetics, University of Oxford, OX1 3PT Oxford, UK.
Keith W VanceDepartment of Life Sciences, University of Bath, BA2 7AY Bath, UK. Electronic address: kwv20@bath.ac.uk.
Francis G SzeleDepartment of Physiology, Anatomy and Genetics, University of Oxford, OX1 3PT Oxford, UK. Electronic address: francis.szele@dpag.ox.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural stem cells (NSCs) in the subventricular zone (SVZ) produce neurons throughout life. However, the epigenetic mechanisms that maintain NSCs and control neurogenesis remain unclear. We previously showed the long non-coding RNA (lncRNA) Paupar and KAP1 transcription co-factor control neuroblastoma cell growth. In the last stages of olfactory bulb (OB) neurogenesis, these two molecules affect rates of neurogenesis. Here we investigated upstream functions with inducible knockout and in vivo knockdown electroporation and molecular analysis. KAP1 and Paupar are expressed in the SVZ, physically interact in SVZ cells, and regulate NSC behavior. KAP1 directly maintains the NSC pool and regulates the expression of genes involved in the cell cycle. Paupar, in turn, maintains stem cell quiescence by restricting lineage progression from stem cells to transit amplifying progenitors (TAPs). These results suggest important roles for KAP1 and Paupar in the control of SVZ NSC maintenance and SVZ-OB neurogenesis.

Indexed as

ChromatinLateral VentriclesNeural Stem CellsNeurogenesisRNA, Long NoncodingTripartite Motif-Containing Protein 28AnimalsMiceOlfactory BulbChromatinRNA, Long NoncodingTrim28 protein, mouseTripartite Motif-Containing Protein 28adult neurogenesischromatinepigeneticsKAP1lncRNAsneural stem cellsPauparquiescencesubventricular zonetranscription

Identifiers

PMID40930062
PMCPMC12447327

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.