Evidence map›Paper›PMID 40930008›Full record

ArticleTranslational oncology2025

Genitourinary system related tumors and coronary atherosclerosis risk: Evidence from a Mendelian randomization study on multi-cohorts.

Shanshan Chen, Yuanyuan Zhao, Yang Fan, Mengchen Zhou

Abstract read
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Article in Translational oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shanshan ChenDepartment of Pathology, Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China.
Yuanyuan ZhaoInstitute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Chinese Academy of Medical Sciences, Wuhan 430030, China.
Yang FanDepartment of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: fanyang@tjh.tjmu.edu.cn.
Mengchen ZhouNational Demonstration Center for Experimental Basic Medical Education, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: zhmc9990@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCVD and cancer are the leading causes of mortality globally. Accumulating evidence suggests that cancer patients have a significantly increased risk of cardiovascular disease. Emerging evidence suggests a bidirectional link between these diseases, possibly mediated by hormonal changes, but further research needs to be performed to explore the specific role of hormone level changes in both diseases.

methodsWe conducted a two-sample Mendelian randomization (MR) analysis using GWAS summary statistics from multiple cohorts of prostate cancer, ER+ breast cancer, and coronary atherosclerosis.

resultsMR analyses (IVW, MR-Egger, WM) demonstrated a significant causal relationship between both prostate and ER+ breast cancer and increased risk of coronary atherosclerosis.

conclusionHormone-related genitourinary tumors may contribute to the development of coronary atherosclerosis. This study is the first to provide causal evidence for such associations using MR.

Indexed as

Coronary atherosclerosisER+ breast cancerMendelian randomizationProstate cancer

Identifiers

PMID40930008
PMCPMC12455002

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.