ArticleNeurology2025
Associations of Chronic Insomnia, Longitudinal Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and influencing factors of insomnia in patients with coronary heart disease: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Insomnia and inflammatory exposure impair spatial memory and cognitive mapping in older adults: a randomized controlled trial.Brain, behavior, and immunity · 2026Trial
- Sleep architecture and self-reported sleep quality are associated with Alzheimer's disease biomarkers in older adults without dementia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Trial
- Apolipoprotein B100 and white matter hyperintensity as distinct mediators of thrombolytic response in acute stroke: preliminary findings.Journal of thrombosis and thrombolysis · 2026Article
- Therapeutic targeting of fibrin-microglia interactions ameliorates Alzheimer's disease-related hyperexcitability and brain network dysfunction.bioRxiv : the preprint server for biology · 2026Article
- HK-ASAP study: protocol for a prospective cohort study on sleep quality, brain reserve and cognitive phenotypes in community-dwelling older adults.BMC geriatrics · 2026Article
- Associations of health literacy with rational drug use awareness and sleep hygiene in older adults: a cross-sectional study.BMC geriatrics · 2026Article
- Organ-Specific Regulation of Systemic Aging: Focus on the Brain, Skeletal Muscle, and Gut.Cells · 2026Review
- Association of 24-hour movement guideline adherence with inhibitory control in older adults: the mediating role of general self-efficacy.Frontiers in psychology · 2026Article
- Association Between Sleep Quality and Cognitive Function in Patients with Hypertension in Rural Areas of Shanxi Province, China: The Chain Mediating Role of Anxiety and Depression.Psychology research and behavior management · 2026Article
- Demyelination and Cognitive Performance in Long COVID Patients with Insomnia and/or Depression.International journal of molecular sciences · 2025Article
- Treatment-induced neuropathy of diabetes overlapping with chronic inflammatory demyelinating polyradiculoneuropathy after rapid glycemic correction: a case report.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
BACKGROUND AND
objectivesThe relationship between insomnia and cognitive decline is poorly understood. We investigated associations between chronic insomnia, longitudinal cognitive outcomes, and brain health in older adults.
methodsFrom the population-based Mayo Clinic Study of Aging, we identified cognitively unimpaired older adults with or without a diagnosis of chronic insomnia who underwent annual neuropsychological assessments (z-scored global cognitive scores and cognitive status) and had quantified serial imaging outcomes (amyloid-PET burden [centiloid] and white matter hyperintensities from MRI [WMH, % of intracranial volume]). We used mixed-effects models to examine associations between baseline insomnia (independently or with interaction with self-reported changes in habitual sleep duration) and longitudinal cognitive z-scores, log-transformed WMH, and amyloid-PET levels while adjusting for multiple confounders, including sleep apnea diagnosis. The risk of incident cognitive impairment (CI) was estimated using the Cox proportional hazards model.
resultsWe included 2,750 participants (mean 70.3 ± 9.7 years old, 49.2% female) in global cognition models and 2,814 in Cox models with median follow-up of 5.6 years. A total of 1,027 and 561 participants were included in WMH and amyloid-PET models, respectively. Insomnia was associated with a 0.011 per year (95% CI -0.020 to -0.001, DISCUSSION: We found an association between insomnia, cognitive decline, and increased risk for CI. Insomnia with reduced sleep was associated with worse cognitive performance and poorer brain health (WMH and amyloid burden) at baseline. Sleeping more than usual was associated with lower WMH burden.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.