Evidence map›Paper›PMID 40929176›Full record

ArticlePloS one2025

Cohort profile: Design and methods for Project HERCULES (Healthcare Exemplar for Recovery from COVID 19 Using Linear Examination Systems): Multi-disciplinary implementation and evaluation of an asynchronous review clinic in NHS eye-care services.

Dhakshi Muhundhakumar, Caroline S Clarke, Grant Mills, Angus I G Ramsay, Kerstin Sailer, Peter Scully, Duncan Wilson, Dun Jack Fu, Siyabonga Ndwandwe, Rosica Pachilova and 12 more

Abstract read
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Dhakshi MuhundhakumarNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and Institute of Ophthalmology University College London, London, United Kingdom.ORCID https://orcid.org/0000-0002-0480-9574
Caroline S ClarkeResearch Department of Primary Care and Population Health, University College London, London, United Kingdom.
Grant MillsBartlett Faculty of the Built Environment, University College London, London, United Kingdom.
Angus I G RamsayResearch Department of Behavioural Science and Health, University College London, London, United Kingdom.
Kerstin SailerBartlett Faculty of the Built Environment, University College London, London, United Kingdom.
Peter ScullyBartlett Faculty of the Built Environment, University College London, London, United Kingdom.
Duncan WilsonBartlett Faculty of the Built Environment, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0001-6041-8044
Dun Jack FuNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and Institute of Ophthalmology University College London, London, United Kingdom.ORCID https://orcid.org/0000-0003-2852-6912
Siyabonga NdwandweResearch Department of Primary Care and Population Health, University College London, London, United Kingdom.
Rosica PachilovaBartlett Faculty of the Built Environment, University College London, London, United Kingdom.
Anne SymonsBartlett Faculty of the Built Environment, University College London, London, United Kingdom.
Steve NapierPatient Representative, Edinburgh, United Kingdom.
Joy AdesanyaMoorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.
Gus GazzardNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and Institute of Ophthalmology University College London, London, United Kingdom.
Robin HamiltonMoorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.
Jonathan WilsonMoorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.
Paul WebsterOperations and Product Management, Ubisense Ltd, Cambridge, United Kingdom.
Peng Tee KhawNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and Institute of Ophthalmology University College London, London, United Kingdom.
Sobha SivaprasadNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and Institute of Ophthalmology University College London, London, United Kingdom.ORCID https://orcid.org/0000-0001-8952-0659
Hari JayaramNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and Institute of Ophthalmology University College London, London, United Kingdom.ORCID https://orcid.org/0000-0003-1998-0670
Paul J FosterNIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and Institute of Ophthalmology University College London, London, United Kingdom.
HERCULES Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo describe the research principles and cohort characteristics of the multi-disciplinary Project HERCULES, an innovative model of safe high-volume outpatient eye-care service for patients with stable chronic eye diseases. Results and analyses of the workstreams within Project HERCULES will be reported elsewhere. The rationale was to improve eye-care capacity in the National Health Service (NHS) in England through the creation of technician-delivered monitoring in a large retail-unit in a London shopping-centre, with remote asynchronous review of results by clinicians (named Eye-Testing and Review through Asynchronous Clinic (Eye-TRAC)). UCL's Bartlett School of Sustainable Construction developed the RIBA (Royal Institute of British Architects) Stage 1 briefing requirements for optimal design specifications for this model of care from first principles research, by analysing ergonomic data from multiple iterations.

methodsPatients aged 18 years or above being monitored in secondary care in Moorfields Eye Hospital NHS Trust for stable glaucoma or retinal conditions were given appointments at Eye-TRAC at Brent Cross, London. Patients were also recruited at City Road and Hoxton Eye-TRACs, as comparators for the motion tracking study. Willing participants were recruited when attending Eye-TRAC from 11th October 2021-1st December 2023, during this time four spatial "iterations," with different configurations of equipment were investigated in succession. Recruited participants provided information on their eye health and quality of life via a questionnaire, as well as agreeing to wear a tracking device. The tracking device was worn for the duration of their clinic visit and along with directly observed timings built a picture of patient and staff flow through the clinic. Rapid qualitative and ethnographic analyses were conducted, drawing on staff, manager and patient interviews and observation of service delivery and challenges. Separately, anonymised data from across the Trust informed an analysis of the impact of opening the Eye-TRACs on Trust-wide waiting times. A nationwide discrete choice experiment was also conducted to assess patients', healthcare providers', and the public's preferences for key service features.. FINDINGS TO DATE AND

conclusion41,567 patients attended the Brent Cross Eye-TRAC between 11th October 2021 and 1st December 2023. 5,539 patients were recruited to Project HERCULES. Spatial configurations promoting independently parallel patient journeys with limited queuing, and direct line of sight between diagnostic stations, supported efficient patient flow. The latter iteration incorporated cataract clinics. Although it added more system complexity, it enabled the evaluation of a further indication for use of Eye-TRAC. FUTURE PLANS: The analysis of trust-wide data on the impact of the Eye-TRACs on waiting times and a nationwide evaluation of stakeholders' preferences regarding diagnostic and monitoring services for stable disease are underway. We will also identify and enumerate limitations in information technology that create bottlenecks in the review process. Qualitative analysis of patient and staff feedback alongside rapid ethnographic work to streamline services is also under way. We seek to develop a framework to help inform NHS guidance and future service planning for ophthalmology and other outpatient diagnostic services. Our data will be analysed to identify enhancements to further streamline operational efficiency.

Indexed as

COVID-19Eye DiseasesAdultAgedCohort StudiesDelivery of Health CareFemaleHumansMaleMiddle AgedSARS-CoV-2State Medicine

Identifiers

PMID40929176
PMCPMC12422467

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.