ArticleAmerican journal of physiology. Cell physiology2025
Differential regulation of NHE3 expression in type 1 and type 2 diabetic intestine: impaired endosomal regulation of NHE3 expression in type 1 diabetes.
Varsha Singh, Ruxian Lin, Laxmi Sunuwar, Jianbo Yang, Mark Donowitz, Rafiquel Sarker
Abstract read
In one paragraphArticle in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors.
Varsha SinghDivision of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0003-0796-2619 Ruxian LinDivision of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Laxmi SunuwarDivision of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Jianbo YangDivision of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Mark DonowitzDivision of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0003-0477-8824 Rafiquel SarkerDivision of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Funding
Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0MTranslational Approaches to Develop Drug Therapy for DiarrheaR24DK099803 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2014 to 2019
$8.9MMechanisms and Correction of Abnormal Bicarbonate Secretion by DRA in DiarrheaR01DK116352 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TSE, CHUNG-MING · 2019 to 2022
$2.2MCystic Fibrosis Foundation (CFF) CF-SINGH20G0HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK099803HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK-116352HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK-89502NIDDK NIH HHS P30 DK089502NIDDK NIH HHS R01 DK116352NIDDK NIH HHS R24 DK099803
6 · The paper itselfAbstract
Chronic diarrhea is a frequent gastrointestinal complication in both type 1 (T1D) and type 2 diabetes (T2D), although the underlying mechanisms differ: T1D is linked to autonomic neuropathy and disrupted transporter regulation, whereas T2D is often linked to medications and intestinal inflammation. Using streptozotocin-induced mouse models of T1D and T2D, we observed increased luminal fluid in the small intestine of both. Given the role of Na
Indexed as
Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2EndosomesIntestinal MucosaSodium-Hydrogen Exchanger 3AnimalsHumansMaleMiceMice, Inbred C57BLSlc9a3 protein, mouseSodium-Hydrogen Exchanger 3diabetic diarrheaNa/H exchanger-3sorting nexin 17streptozotocin
Identifiers
PMID40929175
PMCPMC12490201
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