Evidence map›Paper›PMID 40929173›Full record

ArticlePLoS computational biology2025

Catalyzing computational biology research at an academic institute through an interest network.

Jaroslav Zak, Ian Newman, Daniel J Montiel Garcia, Daniele Parisi, Janet Joy, Steven R Head, Jean-Christophe Ducom, Padmaja Natarajan, Haissi Cui, Sabah Ul-Hasan

Abstract read
In one paragraph

Article in PLoS computational biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jaroslav ZakDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.ORCID 0000-0002-8135-856X
Ian NewmanDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.ORCID 0000-0002-0671-8668
Daniel J Montiel GarciaDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Daniele ParisiDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Janet JoyDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Steven R HeadGenomics Core, The Scripps Research Institute, La Jolla, California, United States of America.
Jean-Christophe DucomInformation Technology Services, The Scripps Research Institute, La Jolla, California, United States of America.
Padmaja NatarajanCenter for Computational Biology and Bioinformatics, The Scripps Research Institute, La Jolla, California, United States of America.
Haissi CuiDepartment of Chemistry, University of Toronto, Toronto, Ontario, Canada.
Sabah Ul-HasanDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.ORCID 0000-0001-6334-452X

Funding

Cancer Research Institute/Irvington Postdoctoral FellowshipHuntsman Cancer FoundationUniversity of Utah
6 · The paper itself

Abstract

Biology has been transformed by the rapid development of computing and the concurrent rise of data-rich approaches such as, omics or high-resolution imaging. However, there is a persistent computational skills gap in the biomedical research workforce. Inherent limitations of classroom teaching and institutional core support highlight the need for accessible ways for researchers to explore developments in computational biology. An analysis of the Scripps Research Genomics Core revealed increases in the total number and diversity of experiments: the share of experiments other than bulk RNA- or DNA-sequencing increased from 34% to 60% within 10 years, requiring more tailored computational analyses. These challenges were tackled by forming a volunteer-led affinity group of approximately 300 academic biomedical researchers interested in computational biology, referred to as the Computational Biology and Bioinformatics (CBB) affinity group. This adaptive group has provided continuing education and networking opportunities through seminars, workshops, and coding sessions while evolving along with the needs of its members. A survey of CBB's impact confirmed the group's events increased the members' exposure to computational biology educational and research events (79% respondents) and networking opportunities (61% respondents). Thus, volunteer-led affinity groups may be a viable complement to traditional institutional resources for enhancing the application of computing in biomedical research.

Indexed as

Academies and InstitutesBiomedical ResearchComputational BiologyGenomicsHumansResearch Personnel

Identifiers

PMID40929173
PMCPMC12422415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.