ArticlePloS one2025
Global, regional, and national burdens of five main digestive system cancers in adolescents and young adults from 1990 to 2021 based on the Global Burden of Disease Study 2021: A cross-sectional study.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the burden and trends of digestive system cancers in adolescents and young adults (AYAs) globally between 1990 and 2021.
methodsData were extracted from the Global Burden of Diseases, Injuries, and Risk Factors Study (1990-2021). We analyzed global, regional, and national disease burdens by calculating the age-standardized incidence (ASIR), mortality (ASMR), and disability-adjusted life years (DALYs) for AYAs. Joinpoint regression calculate the average annual percentage change (AAPC) in incidence, mortality, and DALYs for digestive system cancers in the AYAs. Decomposition analysis illustrate the impact of epidemiological changes, population growth, and population aging on the disease burden.
resultsGlobally, the ASIR (AAPC: 0.37) of AYAs with colorectal cancer (CRC) showed an increasing trend, whereas the ASIR of AYAs with esophageal cancer (EC), gastric cancer (GC), pancreatic cancer (PC), and liver cancer (LC) showed a decreasing trend. The ASMR and age-standardized rates (ASR) of DALYs for all five types of digestive system cancers in AYAs also showed a decreasing trend. By gender, the ASIR for males has increased with an AAPC of 0.84. For the other four types of digestive system cancers in AYAs, both males and females showed a decreasing trend. For AYAs with CRC, the fastest increase in ASIR (AAPC: 0.73) was observed in the 30-34 age group. Regarding SDI regions, we found that the ASIR of AYAs with CRC increased in all five Social Demographic Index (SDI) regions. For AYAs with PC, the burden was increased in low and low-middle SDI. In the AYAs with LC, the ASIR also increased in low-middle SDI. For AYAs with EC and GC, both showed a decreasing trend across all five SDI regions.
conclusionThe study results provide insights into the global distribution and severity of the burden of digestive system cancers among AYAs. The burden of AYAs with CRC is rapidly increasing worldwide, particularly among males, those aged 30-34, and in high-middle SDI. The disease burden varies across different SDI regions. These findings highlight the need for targeted preventive measures and suggest adjusting CRC screening guidelines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.