ArticlePloS one2025
Global disease burden of inflammatory bowel disease in women and women of childbearing age from 1990 to 2021 and its prediction to 2040.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe incidence of inflammatory bowel disease (IBD) peaks between the ages of 15 and 40. This age range coincides with women of childbearing age (WCBA), who face unique challenges like adverse pregnancy outcomes and heightened anxiety. Despite the rising global prevalence of IBD, particularly among younger populations, the burden of IBD among women, especially WCBA, remains underexplored.
methodsThis study utilized data from the Global Burden of Disease (GBD) Study 2021 to examine the prevalence, disability-adjusted life-years (DALYs), and mortality of IBD among women and WCBA from 1990 to 2021. The estimated annual percentage change (EAPC) in age-standardized (AS) rates was calculated to quantify temporal trends. The relationship between the socio-demographic index (SDI) and AS prevalence, DALYs rate, and mortality was assessed using methodologies such as the slope index of inequality, concentration index, frontier analysis, decomposition analysis, and the Bayesian Age-Period-Cohort model.
resultsFrom 1990 to 2021, a significant global decline was observed in the AS prevalence rate (ASPR), DALYs rate (ASDR), and mortality rate (ASMR) of IBD among women. For WCBA, the global prevalence rate decreased slightly, while the DALYs rate increased slightly, and mortality remained unchanged. Significant variations in trends were noted across different SDI and GBD regions. In 2021, the highest ASPR, ASDR, and ASMR for female IBD were reported in Australasia, high-income North America, and Western Europe, respectively. The most pronounced upward trends were observed in East Asia, Australasia, and high-income North America. China, Mauritius, and Kuwait experienced the most significant increases in prevalence, DALYs, and mortality rates among WCBA. Health inequalities across socioeconomic strata decreased, but substantial gaps remained, particularly in India.
conclusionThis study reveals a global decline in the burden of IBD among women and WCBA from 1990 to 2021, with notable regional disparities. The decreasing trends highlight the effectiveness of certain interventions and improvements in healthcare. However, the increasing burden in some regions and for certain age groups, along with significant gaps identified in frontier analysis, emphasize the need for targeted public health strategies and resource allocation to further reduce the burden of IBD among women and WCBA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.