Evidence map›Paper›PMID 40929022›Full record

ReviewJournal of neurotrauma2025

Combining Therapeutic Strategies to Treat the Injured Spinal Cord: A Translational Perspective.

Benjamin C Sherman, Mary Schmidt Read, Daniel J Hoh, James D Guest, Michael A Lane, Lyandysha V Zholudeva

Abstract readReview
In one paragraph

Review in Journal of neurotrauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Benjamin C ShermanDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, Pennsylvania, USA.
Mary Schmidt ReadMagee Rehabilitation, Jefferson Health, Philadelphia, Pennsylvania, USA.
Daniel J HohLillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, Florida, USA.
James D GuestDepartment of Neurological Surgery, University of Miami, Florida, USA.
Michael A LaneDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-1375-6483
Lyandysha V ZholudevaInstitute of Cardiovascular Disease, Gladstone Institutes, San Francisco, California, USA.ORCID 0000-0003-4995-8466

Funding

Neural transplants to promote respiratory plasticity after spinal cord injuryR01NS104291 · NINDS · DREXEL UNIVERSITY · PI LANE, MICHAEL ARON · 2018 to 2022
$1.7M
NINDS NIH HHS R01 NS104291
6 · The paper itself

Abstract

Spinal cord injury (SCI) results in an array of debilitating, sometimes permanent-and at times life-threatening-motor, sensory, and autonomic deficits. A broad range of therapies have been tested pre-clinically, and there has been a significant acceleration in recent years of clinical translation of potential treatments. However, it is widely appreciated among scientists and clinical professionals alike that there likely is no "silver bullet" (single treatment) that will result in complete functional restoration after SCI. The combination of more than one treatment approach, especially treatments that can have distinct beneficial effects, increases the probability of functional improvement. This review highlights the mounting interest in the pre-clinical development and application of combination strategies to treat SCI, and some of the translational efforts made to combine promising therapies for clinical evaluation. Special attention is given to barriers and limitations faced in translating treatments for people living with SCI.

Indexed as

Spinal Cord InjuriesTranslational Research, BiomedicalAnimalsCombined Modality TherapyHumansRecovery of Functioncombinatorial therapyrehabilitationspinal cord injurytranslation

Identifiers

PMID40929022
PMCPMC13003997

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.