Evidence map›Paper›PMID 40928944›Full record

ArticleCell reports2025

Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12.

Andrew J Ingersoll, Devlon M McCloud, Jenny Y Hu, Michael Rape

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Andrew J IngersollDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Devlon M McCloudDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Jenny Y HuDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Michael RapeDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA; California Institute for Quantitative Biosciences (QB3), University of California at Berkeley, Berkeley, CA 94720, USA. Electronic address: mrape@berkeley.edu.

Funding

Function and regulation of the reductive stress responseR01GM151335 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Michael P Rape · 2023 to 2026
$1.2M
Automated High-Throughput, High-Content Confocal/Wide-Field Microscope SystemS10OD021828 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI WEST, MARY · 2017 to 2017
$1.0M
LTQ XL Linear Quadrupole Ion Trap Mass SpectrometerS10RR025622 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI KOHLSTAEDT, LORI · 2009 to 2009
$463k
NCRR NIH HHS S10 RR025622NIGMS NIH HHS R01 GM151335NIH HHS S10 OD021828
6 · The paper itself

Abstract

Centered on the transcription factor NRF2 and its E3 ligase CUL3

Indexed as

Oxidative StressPeptide Elongation FactorsUbiquitin-Protein LigasesAnimalsHEK293 CellsHumansMiceNF-E2-Related Factor 2ProteolysisReactive Oxygen SpeciesSignal TransductionUbiquitinationNFE2L2 protein, humanNF-E2-Related Factor 2Peptide Elongation FactorsReactive Oxygen SpeciesUbiquitin-Protein LigasesCP: CancerCP: Molecular biologyCUL3KEAP1NRF2oxidative stress responseproteasomereactive oxygen speciesROSTRIP12ubiquitin

Identifiers

PMID40928944
PMCPMC12560144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.