Evidence map›Paper›PMID 40928881›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The redox rhythm gates immune-induced cell death distinctly from the genetic clock.

Sargis Karapetyan, Musoki Mwimba, Tianyuan Chen, Zhujun Yao, Xinnian Dong

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Autonomous Redox Rhythms and Their Coupling to the Circadian Clock.Advances in experimental medicine and biology · 2026
    Review
  5. Gating of immune-triggered cell death is a redox rhythm-specific output.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. HScience (New York, N.Y.) · 2024
    Article
  8. HbioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sargis KarapetyanDepartment of Biology, Duke University, Durham, NC 27708.
Musoki MwimbaDepartment of Biology, Duke University, Durham, NC 27708.
Tianyuan ChenDepartment of Biology, Duke University, Durham, NC 27708.
Zhujun YaoDepartment of Biology, Duke University, Durham, NC 27708.
Xinnian DongDepartment of Biology, Duke University, Durham, NC 27708.ORCID 0000-0002-1120-0951

Funding

Salicylic Acid in Immunity and Health: A Small Phytohormone with Big Physiological ImpactsR35GM118036 · NIGMS · DUKE UNIVERSITY · PI Xinnian Dong · 2016 to 2026
$4.0M
HHMI (HHMI) HHMIHHS | NIH | National Institute of General Medical Sciences (NIGMS) R35-GM118036-06NIGMS NIH HHS R35 GM118036NSF (NSF) IOS-2041378NSF (NSF) MCB-2109302
6 · The paper itself

Abstract

Organisms use circadian clocks to synchronize physiological processes to anticipate the Earth's day-night cycles and regulate responses to environmental signals to gain competitive advantage. While divergent genetic clocks have been studied extensively in bacteria, fungi, plants, and animals, an ancient conserved circadian redox rhythm has been recently reported. However, its biological function and physiological outputs remain elusive. Here, we uncovered the coexistence of redox and genetic rhythms with distinct period lengths and transcriptional targets through concurrent metabolic and transcriptional time-course measurements in an

Indexed as

ApoptosisArabidopsisCircadian ClocksCircadian RhythmArabidopsis ProteinsCell DeathCyclopentanesGene Expression Regulation, PlantOxidation-ReductionOxylipinsPlant ImmunitySignal TransductionArabidopsis ProteinsCyclopentanesjasmonic acidOxylipinscircadian clockmetabolismplant immunityprogrammed cell deathredox rhythm

Identifiers

PMID40928881
PMCPMC12452835

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.