Evidence map›Paper›PMID 40928868›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Evolution of cross-tolerance to metals in yeast.

Anna L Bazzicalupo, Penelope C Kahn, Eully Ao, Joel Campbell, Sarah P Otto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Whole-genome combinatorial gene fusions generate novel genes for advanced microbial trait development.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anna L Bazzicalupo *Department of Zoology and Biodiversity Research Centre, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0001-5845-9517
Penelope C Kahn *Department of Zoology and Biodiversity Research Centre, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0009-0002-3782-8699
Eully AoDepartment of Zoology and Biodiversity Research Centre, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0009-0003-2887-1860
Joel CampbellDepartment of Zoology and Biodiversity Research Centre, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Sarah P OttoDepartment of Zoology and Biodiversity Research Centre, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0003-3042-0818

Funding

Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2022-03726
6 · The paper itself

Abstract

Organisms often face multiple selective pressures simultaneously (e.g., mine tailings with multiple heavy metal contaminants), yet we know little about when adaptation to one stressor provides cross-tolerance or cross-intolerance to other stressors. To explore the potential for cross-tolerance, we adapted

Indexed as

Adaptation, PhysiologicalBiological EvolutionMetalsMetals, HeavySaccharomyces cerevisiaeEvolution, MolecularMutationSaccharomyces cerevisiae ProteinsMetalsMetals, HeavySaccharomyces cerevisiae Proteinsadaptationexperimental evolutionpleiotropyrescueSaccharomyces cerevisiae

Identifiers

PMID40928868
PMCPMC12452953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.