Evidence map›Paper›PMID 40928726›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025

Distinct codon usage signatures reflecting evolutionary and pathogenic adaptation in the Acinetobacter baumannii complex.

Ujwal Dahal, Anuj Sharma, Karan Paul, Anu Bansal, Shelly Gupta

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Ujwal DahalSchool of Bioengineering and Biosciences, Department of Biochemistry, Lovely Professional University, Punjab, 144411, India.
Anuj SharmaDepartment of Medical Laboratory Technology, DAV University, Punjab, 144012, India.
Karan PaulDepartment of Biochemistry, DAV University, Punjab, 144012, India.
Anu BansalSchool of Bioengineering and Biosciences, Department of Biochemistry, Lovely Professional University, Punjab, 144411, India.
Shelly GuptaSchool of Bioengineering and Biosciences, Department of Biochemistry, Lovely Professional University, Punjab, 144411, India. shels.thap@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study investigates codon usage and amino acid usage bias in the genus Acinetobacter to uncover the evolutionary forces shaping these patterns and their implications for pathogenicity and biotechnology.

methodsCodon usage patterns were examined in representative genomes of the genus Acinetobacter using standard codon bias indices, including GC content, relative synonymous codon usage (RSCU), effective number of codons (ENC), and codon adaptation index (CAI). Neutrality and parity plots were employed to evaluate the relative influence of mutational pressure and natural selection on codon preferences. Codon pair usage and amino acid composition were assessed to identify functional constraints, while phylogenetic relationships were inferred using gyrB gene sequences to explore evolutionary divergence in the genus Acinetobacter.

resultsA dynamic GC content range was observed, from 35.71% in Acinetobacter equi to 46.21% in Acinetobacter indicus, with the Acinetobacter baumannii complex. maintaining a balanced GC distribution (39%), suggesting genomic stability. AT-rich preferred codons indicated selective pressure favouring specific codons, while correlations with GC composition underscored the role of mutational bias. CAI values >0.5 in highly expressed genes denote bias toward optimal codons. Codon pair usage revealed distinctive patterns, with notable similarities within the Acinetobacter baumannii complex, indicating functional congruence. The gyrB phylogeny clustered Acinetobacter baumannii complex despite evolutionary divergence.

conclusionCodon usage in the genus Acinetobacter reflects a complex interplay of mutational and selective forces, shaping genomic and functional diversity. Distinct disparities in codon usage between pathogenic and non-pathogenic species point to genomic signatures that may underpin virulence, warranting further investigation into their pathogenic potential.

Indexed as

AcinetobacterAcinetobacter baumanniiAdaptation, PhysiologicalCodonCodon UsageEvolution, MolecularAcinetobacter InfectionsBase CompositionDNA GyraseGenome, BacterialHumansPhylogenySelection, GeneticCodonDNA GyraseACB complexCodon usageGyrBPhylogenyWhole genus Acinetobacter

Identifiers

PMID40928726

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.