Prevalence and molecular characterization of methicillin-resistant Staphylococcus aureus (MRSA) in acute and chronic sinusitis.

H A Mustafa, S M Ali

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 authors.

H A MustafaDepartment of Medical Lab Technology, Kalar Technical College, Garmian Polytechnic University, Kalar, 46001, Kurdistan Region, Iraq.

S M AliDepartment of Medical Lab Technology, College of health and medical technology, Sulaimani Polytechnic University, Sulaimani, 46001, Kurdistan Region, Iraq. seenaa.ali@spu.edu.iq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSinusitis is a common respiratory infection increasingly associated with antibiotic-resistant Staphylococcus aureus, posing significant treatment challenges. The emergence of methicillin-resistant S. aureus (MRSA) in sinus infections necessitates comprehensive profiling of resistance patterns to guide effective therapy. This study aimed to determine the prevalence of MRSA in acute and chronic sinusitis, to characterize the antibiotic susceptibility patterns of S. aureus isolates, and to detect the presence of Sa442, mecA, femA, msrA, tetK and tetM genes. METHODS AND

resultsMiddle meatus swabs were collected from 81 patients with sinusitis. To reveal the spectrum of bacterial species, samples were first cultured on various media. All resulting isolates were then identified using the VITEK

conclusionsThis study identified a high prevalence of multi-drug resistant MRSA in sinusitis, characterized by the frequent detection of mecA, tetK and tetM genes. These findings challenge empirical therapy and highlight the need for molecular diagnostics.

Indexed as

Methicillin-Resistant Staphylococcus aureusSinusitisStaphylococcal InfectionsAcute DiseaseAdultAgedAnti-Bacterial AgentsBacterial ProteinsChronic DiseaseFemaleHumansMaleMicrobial Sensitivity TestsMiddle AgedPrevalenceAnti-Bacterial AgentsBacterial ProteinsAcute sinusitisAntibiotic resistance genesChronic sinusitisMiddle meatus swabMRSA

Identifiers

PMID40928716

DOI10.1007/s11033-025-10994-2

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