ArticleInfectious diseases and therapy2025
Associated Factors of Cognitive Frailty in People Living with HIV Aged 50 and Older: A Cross-Sectional Study.
Article in Infectious diseases and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Relationship between self-perceptions of ageing and interoception among older people living with HIV: a latent profile analysis.BMC public health · 2026Article
- Frailty among adult people living with HIV in Tanzania: a single-centred hospital-based cross-sectional study.BMJ public health · 2026Article
- Predictors of mild cognitive impairment in older adults living with HIV and multimorbidity: a comparative analysis using logistic regression and decision tree models.Frontiers in public health · 2026Article
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10 authors.
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Abstract
introductionCognitive frailty (CF), which typically precedes dementia and functional decline, serves as a more robust predictor of adverse health outcomes compared to physical frailty alone, representing a critical challenge in promoting healthy aging among older people living with HIV (PLWH) aged ≥ 50 years. This study aimed to investigate the prevalence of cognitive frailty and identify its associated factors among PLWH aged ≥ 50 years.
methodsA convenience sample of 344 PLWH ≥ 50 years was recruited from a tertiary Grade A hospital in Zunyi, China. Physical frailty: evaluated via the Fatigue, Resistance, Ambulation, Illnesses, and Loss of Weight (FRAIL) Scale; Cognitive function: assessed via the Chinese version of the Montreal Cognitive Assessment (MoCA). Participants were divided into the cognitive frailty group (FRAIL score ≥ 3 and MoCA score < 26), the non-cognitive frailty group. Binary logistic regression analysis was conducted with SPSS 29.0 to identify factors associated with CF.
resultsThe prevalence of CF among the 344 PLWH aged ≥ 50 years was 37.5%. Regression analysis revealed that the following associated factors (p < 0.05) were independent risk factors for CF in PLWH aged ≥ 50 years: age, education level, weekly frequency of physical activity ≤ 2 sessions, depression, sleep disorders, and EFV-containing regimens.
conclusionsCognitive frailty is highly prevalent among PLWH aged ≥ 50 years. Early screening and comprehensive healthcare interventions targeting modifiable risk factors are crucial for delaying or reversing CF progression in this population.
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