Evidence map›Paper›PMID 40928686›Full record

ArticleEndocrine2025

Endothelial function and peak heart rate in normal-weight women with polycystic ovary syndrome and normal-weight controls.

Georgios Valsamakis, Dimitrios Terentes-Printzios, George Paltoglou, Thomas M Barber, Polina Pavli, Ioanna Dima, Chrysoula Koukoula, Ioannis Papassotiriou, Alexandra Bargiota, Ioannis Fatouros and 3 more

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Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Georgios Valsamakis2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, "Aretaieion" University Hospital, Athens, 11528, Greece. gedvalsamakis@yahoo.com.
Dimitrios Terentes-Printzios1st Department of Cardiology, Medical School, Hippokration Hospital, National and Kapodistrian University of Athens, Athens, 11527, Greece.
George Paltoglou2nd Department of Pediatrics, National and Kapodistrian University of Athens, "P. & A. Kyriakou" Children's Hospital, Athens, Greece.
Thomas M BarberDivision of Biomedical Sciences, Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, Warwick Medical School, University Hospitals Coventry and Warwickshire, Coventry, Coventry, UK.
Polina Pavli2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, "Aretaieion" University Hospital, Athens, 11528, Greece.
Ioanna Dima1st Department of Cardiology, Medical School, Hippokration Hospital, National and Kapodistrian University of Athens, Athens, 11527, Greece.
Chrysoula KoukoulaUnit of Endocrinology, Diabetes Mellitus and Metabolism, Aretaieion Hospital, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Ioannis PapassotiriouFirst Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Alexandra BargiotaDepartment of Endocrinology and Metabolic Diseases, Larissa University Hospital, University of Thessaly, Larissa, Greece.
Ioannis FatourosDepartment of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.
Nikolaos F Vlahos2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, "Aretaieion" University Hospital, Athens, 11528, Greece.
Charalampos Vlachopoulos1st Department of Cardiology, Medical School, Hippokration Hospital, National and Kapodistrian University of Athens, Athens, 11527, Greece.
George MastorakosUnit of Endocrinology, Diabetes Mellitus and Metabolism, Aretaieion Hospital, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Funding

Ethnikon and Kapodistriakon University of Athens No 1535
6 · The paper itself

Abstract

contextAssess endothelial dysfunction in normal weight women with polycystic ovary syndrome (PCOS) after exercise.

objectiveTo compare brachial artery Flow Mediated Dilatation (FMD) between normal-weight with PCOS and normal-weight control women. The secondary endpoint is to explore if FMD shows correlation with blood pressure, heart rate, maximal oxygen consumption (VO2 max), and VO2 75%. DESIGN AND PATIENTS: Thirty normal-weight PCOS and thirty BMI- and age- matched control women were studied via brachial artery FMD before and after treadmill exercise.

settingObstetrics and Gynecology.

interventionsSubjects before and after treadmill exercise had measurements of brachial artery FMD, heart rate, VO2 max, peak heart rate. Oral glucose tolerance test was performed.

main outcome measureFlow Mediated Dilatation change after a single bout treadmill exercise.

resultsMean FMD values decreased significantly at 30 min following exercise compared to baseline in controls, while they did not change in PCOS women. FMD was lower both at baseline and after exercise in PCOS group. Backwards multiple linear regression analysis revealed peak heart rate as the best negative predictor of baseline FMD in PCOS, while it was a positive predictor in controls. In controls peak heart rate measurements were the best positive predictor of Delta Area Under the Curve FMD during exercise.

conclusionsThese data could show a defective endothelial system in normal-weight women with PCOS. As heart rate and endothelial function are both components of sympathetic nervous system activity, the negative correlation between them, compared to controls, could imply a possible sympathetic system dysfunction in PCOS.

Indexed as

Endothelium, VascularHeart RatePolycystic Ovary SyndromeAdultBlood PressureBody WeightBrachial ArteryExerciseExercise TestFemaleHumansOxygen ConsumptionVasodilationYoung AdultEndothelial dysfunctionFMDNormal-weight PCOSSympathetic nervous systemVO2max

Identifiers

PMID40928686

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.