ArticleAngiogenesis2025
Vasculogenic potential of adipose tissue derived stem cells from patients with chronic spinal cord injury and pressure injuries.
Article in Angiogenesis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- The role of endothelial colony forming cells in the treatment of limb ischaemia: challenges in clinical translation.Stem cells translational medicine · 2026Review
- Stromal Vascular Fraction Across Different Clinical Indications: A Pro-RegenerativeJournal of clinical medicine · 2026Article
- Human Subcutaneous Derived Stromal Vascular Fraction Endothelial Cells Display Venous and Arterial Markers in Culture and 3D Capillaries.Tissue engineering and regenerative medicine · 2026Article
- Dysfunctional vasculogenesis in adipose-derived stem cells from chronic spinal cord injury patients: implications for autologous cell therapy.Angiogenesis · 2025Article
Corrections and comments
- Commented on by
Authors and funding
13 authors.
Funding
Abstract
Limited vascularization and ischemia are major contributors to the chronicity of wounds, such as ulcers and traumatic injuries, which impose significant medical, social, and economic burdens. These challenges are particularly pronounced in patients with spinal cord injury (SCI), a disabling condition associated with vascular dysfunction, infections, and impaired peripheral circulation, complicating the treatment of pressure injuries (PIs) and the success of reconstructive procedures like grafts and flaps. Regenerative medicine aims to address these issues by identifying effective cellular therapies to restore vascular beds. Among these, cells from the stromal vascular fraction (SVF) of adipose tissue (AT) are promising due to their abundance of angiogenic and vasculogenic cells, including mesenchymal stem cells (MSCs) and endothelial colony-forming cells (ECFCs). This study evaluated the vasculogenic potential of AT-derived cellular fractions isolated via enzymatic digestion of white adipose tissue (WAT). We compared adipose-derived stem cells (ASCs) cultured from SVF with a combination of ECFCs and MSCs, expanded separately and transplanted in a 40:60 ratio. Results showed that while ASCs promote angiogenesis and vasculogenesis, the ECFC/MSC combination is superior, consistently forming perfused vascular beds in subcutaneous implants in nude mice. Furthermore, ECFCs and MSCs extracted from small amounts of WAT in SCI patients with PIs demonstrated similar functionality and vasculogenic potential to cells from healthy controls. These findings highlight the potential of AT-derived ECFCs and MSCs in autologous cell therapies, offering a promising avenue for advancing vascular regeneration in patients with SCI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.