ArticleNaunyn-Schmiedeberg's archives of pharmacology2026
Evaluation of clozapine forgiveness under imperfect adherence scenarios: a population pharmacokinetic simulation study.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
Funding
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Abstract
Clozapine, the only drug approved by the FDA for treatment-resistant schizophrenia, operates within a narrow therapeutic range (0.35-0.60 mg/mL) and requires titration from 12.5 to 300-450 mg daily in two divided doses. Non-adherence, driven by adverse effects and logistic barriers, often manifests as missed or delayed doses. Clozapine's forgiveness, i.e., its capacity to sustain efficacy despite dosing errors, is poorly quantified. This study simulated the pharmacokinetics (PK) of clozapine to assess forgiveness across dosing scenarios. A one-compartment PK model (CL = 8.3 L/h, V
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Registered trials
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