Evidence map›Paper›PMID 40928633›Full record

ArticleTranslational stroke research2025

Cisternal Contrast-Enhanced MRI Reveals Post-Stroke Glymphatic Impairment and Compensatory Metabolic Waste Clearance via Microglia/Macrophages.

Chengfeng Sun, Chanchan Li, Luyi Lin, Lekang Yin, Jiaojiao Li, Yan Ren, Weijun Tang, Yanmei Yang

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Article in Translational stroke research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Chengfeng Sun *Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Chanchan Li *Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Luyi LinDepartment of Radiology, Shanghai Cancer Center, Fudan University, Shanghai, China.
Lekang YinDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Jiaojiao LiDepartment of Emergency, Shanghai Jingan District Central Hospital, Shanghai, China.
Yan RenDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Weijun TangDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Yanmei YangDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China. yym9876@sohu.com.

Funding

National Natural Science Foundation of China 81771788
6 · The paper itself

Abstract

Recent studies have shown that the glymphatic system plays a crucial role in driving hyperacute edema after ischemic stroke. This has sparked interest in understanding how this system changes in later phases of ischemic stroke. In this study, we utilized cisternal contrast-enhanced magnetic resonance imaging (CE-MRI) and immunofluorescence staining to investigate glymphatic system alterations at subacute and chronic phases of ischemic stroke. Middle cerebral artery occlusion (MCAO) for 90 min in Sprague-Dawley rats was used to mimic ischemic stroke. A total of 20 rats were randomly divided into four groups: sham group, MCAO 1-week group, MCAO 2-week group, and MCAO 2-month group. Our results showed the glymphatic system was spatially and temporally heterogeneously impaired in the peri-infarct area at subacute phase, even lasting for chronic phase. Specially, we found retention of contrast after cisternal CE-MRI in the infarct core and peri-infarct area at subacute phase of ischemic stroke, which corresponded to the distribution of microglia/macrophages. Our results indicated that ischemic stroke contributed to long-term glymphatic impairment and waste retention, and cisternal CE-MRI delayed enhancement could reflect the retention of waste and activation of microglia/macrophages in this process. These findings suggest cisternal CE-MRI might be a useful tool for investigating the interaction between the glymphatic system and microglia/macrophages in waste clearance and neuroinflammation after brain insult.

Indexed as

Glymphatic SystemInfarction, Middle Cerebral ArteryIschemic StrokeMacrophagesMagnetic Resonance ImagingMicrogliaStrokeAnimalsContrast MediaDisease Models, AnimalMaleRatsRats, Sprague-DawleyContrast MediaCisternal CE-MRIGlymphatic systemIschemic strokeMetabolic waste clearanceMicroglia/macrophages

Identifiers

PMID40928633

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.