Evidence map›Paper›PMID 40928580›Full record

ArticleDeveloping world bioethics2026

Making Advanced Therapies Affordable and Accessible: Two Strategic Approaches.

Ubaka Ogbogu, Lauren Albrecht

Abstract read
In one paragraph

Article in Developing world bioethics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ubaka OgboguFaculty of Law, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0001-7764-6799
Lauren AlbrechtFaculty of Law, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-6088-291X

Funding

This study was supported by a Government of Canada's New Frontiers in Research Fund-Transformation Stream (NFRFT-2022-00327) grant and the Stem Cell Network (Canada) Translation and Society Team Award.
6 · The paper itself

Abstract

This article explores two complementary strategies for addressing the affordability and access challenges facing advanced therapies. As high development costs and limited market access have led to the withdrawal of several therapies, the article examines how these barriers create 'valleys of death' that prevent innovation from reaching patients. Through the case of Glybera and other examples, it outlines a rehabilitative approach focused on reforming current systems through improved reimbursement schemes, regulatory streamlining, and more efficient manufacturing. It also presents a transformative approach that embeds affordability and access from the beginning of the research and development process, encouraging local innovation, equitable intellectual property practices, and adaptive regulatory frameworks. Lessons from the COVID-19 vaccine experience demonstrate the real-world potential of these strategies to ensure that promising therapies are not only developed, but also equitably delivered worldwide.

Indexed as

COVID-19Health Services AccessibilityCOVID-19 VaccinesHumansIntellectual PropertySARS-CoV-2COVID-19 Vaccinesaccess and affordabilityadvanced therapiesCOVID‐19 vaccineglobal health equityGlyberamedicines reimbursement schemesvalley of death

Identifiers

PMID40928580
PMCPMC12980559

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.