Evidence map›Paper›PMID 40928574›Full record

ArticleAnnals of surgical oncology2026

Trends in Patient-Reported Outcomes After Breast-Conserving Surgery and Partial-Breast Versus Whole-Breast Irradiation.

Julia M Chandler, Minji Kim, Varadan Sevilimedu, Tiana V Le, Jonas A Nelson, Lior Z Braunstein, Monica Morrow, Minna K Lee, Audree B Tadros

Abstract readComparative Study
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Julia M ChandlerBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Minji KimPlastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Varadan SevilimeduDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tiana V LeBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jonas A NelsonPlastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lior Z BraunsteinExternal Beam Radiotherapy Service, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Monica MorrowBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Minna K LeeBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Audree B TadrosBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. tadrosa@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748NCI NIH HHS P30CA008748
6 · The paper itself

Abstract

backgroundAlthough several trials have demonstrated the oncologic safety of partial-breast irradiation (PBI) compared with whole-breast irradiation (WBI), data on patient-reported outcomes are mixed. Here we compare breast satisfaction and chest well-being using the BREAST-Q questionnaire among patients undergoing PBI versus WBI. PATIENTS AND

methodsWe identified patients undergoing lumpectomy and radiation, and analyzed their BREAST-Q scores preoperatively and postoperatively at 6 months, 1 year, 2 years, and 3 years. We stratified patients by type of radiation, and compared breast satisfaction and chest well-being scores over time, and with univariate and multivariate analyses (MVA).

resultsFrom 2017 to 2022, 6374 patients underwent lumpectomy and radiation, and responded to the BREAST-Q at ≥ 1 time point. For both breast satisfaction and chest well-being, patients undergoing PBI had higher preoperative scores. For breast satisfaction, scores increased for both groups postoperatively and remained above baseline through 3 years of follow-up; for chest well-being, scores decreased postoperatively and gradually increased. On MVA, radiation type was not significantly associated with either breast satisfaction or chest well-being at any postoperative time point. At the 2-year postoperative time point, receipt of adjuvant chemotherapy was associated with worse breast satisfaction, and BMI < 20 was associated with improved chest well-being.

conclusionsPatients undergoing PBI and WBI had similar breast satisfaction and chest well-being at all postoperative time points. Other patient- and treatment-related variables such as body mass index (BMI), axillary surgery, and need for chemotherapy were significantly associated with long-term breast satisfaction and chest well-being. These findings support the use of PBI as an alternative to WBI in terms of patient-reported outcomes in eligible patients.

Indexed as

Breast NeoplasmsMastectomy, SegmentalPatient Reported Outcome MeasuresPatient SatisfactionAdultAgedFemaleFollow-Up StudiesHumansMiddle AgedPrognosisQuality of LifeRadiotherapy, AdjuvantSurveys and QuestionnairesBreast-conserving therapyPartial-breast irradiationPatient-reported outcomesWhole-breast irradiation

Identifiers

PMID40928574
PMCPMC13650987

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.