Evidence map›Paper›PMID 40928519›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025

The expression of GSTP1 in the filum terminale of children with tethered cord syndrome.

Wang Zili, Jia Weidong, Zhang Yu, Xia Bing, Wei Liangkui, Li Jianfeng, Liu Fuyun

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Wang ZiliDepartment of Orthopedics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jia WeidongDepartment of Spine Surgery, Zhumadian Central Hospital, Zhumadian, China.
Zhang YuDepartment of Anesthesiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xia BingDepartment of Orthopedics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Wei LiangkuiEmergency Department, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Li JianfengDepartment of Pain, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Liu FuyunDepartment of Orthopedics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China. liufuyun111@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyze the filum terminale (FT) of children with tethered cord syndrome (TCS) and aborted fetuses without neurological disorders in order to investigate the expression of significantly differentially expressed proteins in the FT under both pathological and physiological conditions.

methodsAccording to the inclusion and exclusion criteria, 35 FT samples were selected, and the samples were subjected to immunohistochemistry and H&E staining. The data were analyzed using one-way analysis of variance, and P < 0.05 was considered statistically significant.

resultsOne out of 7 FTs in the aborted fetus group had fibrotic changes, 10 out of 14 FTs in the tethered cord (TC) group had fibrotic changes, and 14 out of 14 FTs in the TCS group had fibrotic changes. Most of the elastic fibers were missing and the degree of fibrotic changes was most severe in the TCS group, while the FTs in the TC group and the fetal group mainly showed only mild fibrosis. There were 10 cases (71.4%) showing strong expression of glutathione-S-transferase Pi 1 (GSTP1) in the TCS group, 8 cases (57.1%) of GSTP1 expression in children with TC, and 1 case (14.3%) of GSTP1 expression in the aborted fetus group.

conclusionsIn the TCS group, the FTs showed fibrotic changes, disorder, and increased adipose tissue, and most of the lesions were considered severe. The expression of GSTP1 was highest in the TCS group.

Indexed as

Cauda EquinaGlutathione S-Transferase piNeural Tube DefectsAborted FetusChildChild, PreschoolFemaleFibrosisHumansInfantMaleGlutathione S-Transferase piGSTP1 protein, humanFiber tissueFibrosis changesFilum terminaleGlutathione-S-transferase Pi 1Tethered cord syndrome

Identifiers

PMID40928519

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