Evidence map›Paper›PMID 40928511›Full record

ArticleHerz2026

Tetrandrine has protective role in myocardial ischemia/reperfusion injury via the TRPV2/Ca

Wenbing Jiang, Lelin Jiang, Yiying Liu, Xiaoli Zhao, Shu'e Huang, Ying Liu, Huanghui Sun, Fanlu Guan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Herz, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenbing JiangDepartment of Cardiology, Wenzhou Integrated Traditional Chinese and Western Medicine Hospital, 325000, Wenzhou, Zhejiang, China. jiangwb919@wmu.edu.cn.
Lelin JiangThe Second Clinical College of Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China.
Yiying LiuPostgraduate Training Base Alliance of Wenzhou Medical University (Wenzhou Central Hospital), 325000, Wenzhou, Zhejiang, China.
Xiaoli ZhaoPostgraduate Training Base Alliance of Wenzhou Medical University (Wenzhou Central Hospital), 325000, Wenzhou, Zhejiang, China.
Shu'e HuangDepartment of Cardiology, Wenzhou Integrated Traditional Chinese and Western Medicine Hospital, 325000, Wenzhou, Zhejiang, China.
Ying LiuDepartment of Cardiology, Wenzhou Integrated Traditional Chinese and Western Medicine Hospital, 325000, Wenzhou, Zhejiang, China.
Huanghui SunDepartment of Heart Function Examination, The Theorems Clinical College of Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China.
Fanlu GuanDepartment of Cardiology, The Third Clinical College of Wenzhou Medical University, 326000, Wenzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe protective function of the tetrandrine (TET)-mediated transient receptor potential vanilloid 2 (TRPV2) channel in myocardial ischemia/reperfusion injury (MI/RI) has been established in numerous investigations. The objective of the current study was to explain how TRPV2 further modulates downstream factors to influence the progression of MI/RI.

methodsTo this end, an MI/RI model in rats and a hypoxia-reoxygenation (H/R) cell model in H9c2 cells were constructed. Based on western blotting analyses, the effects of TRPV2 on the levels of apoptosis-related proteins as well as calcineurin and nuclear factor of activated T cells (NFAT) were ascertained. Evans blue/triphenyltetrazolium chloride (TTC) double staining and H&E staining were, respectively, used to examine the pathological changes and infarction size of myocardial tissues in rats. Cardiomyocyte apoptosis was assessed with TUNEL assays and flow cytometry. Ca

resultsDownregulated TRPV2 showed a significant ameliorative effect on cardiomyocyte histopathology and infarction area. Cardiomyocyte apoptosis, Ca

conclusionThese findings shed light on the possible mechanisms behind the TET-mediated TRPV2 channel in MI/RI, indicating that TET has protective functions through downregulation of TRPV2 expression and suppression of the Ca

Indexed as

BenzylisoquinolinesCalcineurinMyocardial Reperfusion InjuryNFATC Transcription FactorsTRPV Cation ChannelsAnimalsApoptosisCalciumDisease Models, AnimalMaleMyocytes, CardiacRatsRats, Sprague-DawleySignal TransductionBenzylisoquinolinesCalcineurinCalciumNFATC Transcription FactorstetrandrineTrpv2 protein, ratTRPV Cation ChannelsApoptosisCa2+/calcineurin/NFAT pathwayMyocardial ischemia/reperfusion injuryOxidative stressTetrandrineTRPV2

Identifiers

PMID40928511
PMCPMC12982206

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.