Evidence map›Paper›PMID 40928442›Full record

ArticleJACC. Case reports2025

First Transcatheter Pulmonary Valve Replacement in Tanzania: Feasibility of Advanced Cardiac Interventions in Resource-Limited Settings.

Megha B Unadkat, Deogratias Nkya, Stella Mongella, Joao D Fontes, Gilson Santos, Christopher Leemars, Joanna Ghobrial, Peter Kisenge

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Megha B UnadkatDepartment of Pediatric Cardiology, Jakaya Kikwete Cardiac Institute (JKCI), Dar es Salaam, Tanzania. Electronic address: meghabunadkat@gmail.com.
Deogratias NkyaDepartment of Pediatric Cardiology, Jakaya Kikwete Cardiac Institute (JKCI), Dar es Salaam, Tanzania; Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania.
Stella MongellaDepartment of Pediatric Cardiology, Jakaya Kikwete Cardiac Institute (JKCI), Dar es Salaam, Tanzania.
Joao D FontesLenox Hill Hospital, Cardiovascular Medicine, Manhattan, New York, USA.
Gilson SantosDepartment of Anesthesiology, Americas Medical City, Rio De Janeiro, Brazil.
Christopher LeemarsCleveland Clinic, Cardiac Catheterization, Cleveland, Ohio, USA.
Joanna GhobrialCleveland Clinic, Adult Congenital Heart Disease, Cleveland, Ohio, USA.
Peter KisengeDepartment of Adult Cardiology, Jakaya Kikwete Cardiac Institute (JKCI), Dar es Salaam, Tanzania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscatheter pulmonary valve implantation (TPVI) has emerged as a viable alternative to surgical pulmonary valve replacement for patients with congenital heart disease and right ventricular outflow tract dysfunction. However, its adoption in low-resource settings has been limited. CASE SUMMARY: We report the first successful TPVI procedures in Tanzania. Case 1 involved a 16-year-old male with Noonan syndrome and prior homograft conduit for pulmonary atresia and ventricular septal defect. Case 2 was a 16-year-old female with repaired Tetralogy of Fallot who had undergone prior surgical valve replacement with a Trifecta valve. Both patients presented with severe right ventricular outflow tract dysfunction and underwent successful TPVI with a 20-mm Melody valve (Medtronic) without complications. Postprocedural imaging confirmed hemodynamic improvement and symptom relief. DISCUSSION: These first-in-country cases demonstrate the feasibility of TPVI in resource-limited settings. Broader implementation will require cost-reduction strategies, industry collaboration, and provider training to overcome financial and technical barriers. TAKE-HOME MESSAGE: TPVI can be safely implemented in low- and middle-income countries through structured planning and partnerships.

Indexed as

congenital heart diseasepulmonary atresiapulmonary regurgitationpulmonary stenosisTetralogy of Fallottranscatheter pulmonary valve implantation

Identifiers

PMID40928442
PMCPMC12793837

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.