Evidence map›Paper›PMID 40928365›Full record

Trial reportInternational journal of surgery (London, England)2026

Three-dimensionally printed navigational template technology for lung biopsy: a noninferiority, randomized trial.

Shenghao Huang, Bin Chen, Haoran E, Weiyan Sun, Long Xu, Zihan Guo, Xinchen Shen, Lei Zhang, Jiajun Deng, Yunlang She and 2 more

Abstract readRandomized Controlled TrialEquivalence Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of surgery (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

12 authors.

Shenghao HuangDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Bin ChenDepartment of Oncology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Haoran EDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Weiyan SunDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Long XuDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Zihan GuoDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Xinchen ShenDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Lei ZhangDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Jiajun DengDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Yunlang SheDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Deping ZhaoDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Chang ChenDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0003-2841-1250

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPercutaneous transthoracic needle biopsy (PTNB) guided by computed tomography (CT) greatly depends on the operators' skill for accuracy. This study aimed to evaluate whether three-dimensionally (3D)-printed navigational templates for PTNB achieve diagnostic yield comparable to conventional CT guidance. MATERIALS AND

methodsConducted from 1 November 2020 to 27 July 2023, this noninferiority randomized clinical trial included 159 patients with peripheral lung masses (≥30 mm). The analyses were performed using intention-to-treat (ITT) and per-protocol approaches.

resultsA total of 150 patients were enrolled, with 144 analyzed in ITT analysis (72 per group). Diagnostic yields were 91.7% in the template-guided group and 94.4% in the CT-guided group, confirming noninferiority (difference, -2.8%; 95% CI, -11.1%-5.5%). There was no significant difference in biopsy deviation between the two groups (9.6 [4.6] mm vs 10.1 [3.4] mm; P = 0.505). The template-guided group exhibited shorter procedural duration (10.2 vs. 12.8 minutes; P < 0.001) and reduced radiation exposure (dose-length product: 233.4 vs. 320.1 mGy × cm; P < 0.001). Complication rates, including pneumothorax and hemorrhage, did not significantly differ between groups.

conclusions3D-printed navigational templates for lung biopsy demonstrated noninferior diagnostic efficacy compared to CT guidance, significantly reducing procedure duration and radiation exposure. This technology enhances biopsy efficiency, benefiting operators with limited experience.

Indexed as

Image-Guided BiopsyLungLung NeoplasmsPrinting, Three-DimensionalAdultAgedBiopsy, NeedleFemaleHumansMaleMiddle AgedRadiography, InterventionalTomography, X-Ray Computed3D-printed navigational templateCT-guided biopsydiagnostic yieldlung biopsypercutaneous transthoracic needle biopsyradiation exposure

Identifiers

PMID40928365
PMCPMC12825797

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.