ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2025
Significance of Th1 and Th2 Cell Densities and Th1/Th2 Cytokine Profiles in Colorectal Cancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Aino OjanperäTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0009-0000-9399-2253
Päivi SirniöTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0000-0002-3988-3782
Hanna ElomaaResearch Program in Systems Oncology, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-5378-7703
Ville K ÄijäläTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0009-0005-7664-8027
Henna KarjalainenTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0009-0008-4694-6703
Vilja V TapiainenTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0009-0003-6306-6525
Meeri KastinenTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0009-0007-0954-5612
Akseli KehusmaaTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0009-0004-9415-7283
Oskari RahkolaTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0009-0004-0865-3302
Vesa-Matti PohjanenTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0000-0002-4129-4346
Maarit AhtiainenCentral Finland Biobank, Hospital Nova of Central Finland, Well Being Services County of Central Finland, Jyväskylä, Finland.ORCID 0000-0002-3263-2307
Olli HelminenTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0000-0001-9544-6475
Erkki-Ville WirtaDepartment of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.ORCID 0000-0002-2255-6136
Jukka RintalaTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0000-0003-1865-8444
Sanna MeriläinenTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0000-0002-5418-4373
Raila AroTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0000-0001-8193-8460
Reetta HäiväläTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0009-0001-4537-1214
Juha SaarnioTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0000-0002-8443-3625
Tero RautioTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0000-0003-4441-9412
Toni T SeppäläFaculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland.ORCID 0000-0002-4940-3498
Jan BöhmDepartment of Pathology, Hospital Nova of Central Finland, Well Being Services County of Central Finland, Jyväskylä, Finland.ORCID 0000-0001-9664-588X
Jukka-Pekka MecklinDepartment of Education and Research, Well Being Services County of Central Finland, Jyväskylä, Finland.ORCID 0000-0003-4895-2249
Anne TuomistoTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0000-0002-9949-1887
Markus J MäkinenTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0000-0002-9200-4118
Juha P VäyrynenTranslational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.ORCID 0000-0002-8683-2996
Funding
Emil Aaltosen Säätiö (Emil Aaltonen Foundation) 220257PJane ja Aatos Erkon Säätiö (J&AE) 21002Sigrid Juséliuksen Säätiö (Sigrid Jusélius Stiftelse) 230229Sigrid Juséliuksen Säätiö (Sigrid Jusélius Stiftelse) 240241Sigrid Juséliuksen Säätiö (Sigrid Jusélius Stiftelse) 250264Suomen Lääketieteen Säätiö (Finnish Medical Foundation) 6021
6 · The paper itself
Abstract
backgroundT-cell densities are associated with colorectal cancer outcome, but the significance of specific Th cell subsets is incompletely understood. We aimed to investigate the role of Th1 and Th2 cells and associated cytokine profiles.
methodsWe used multiplex IHC to identify Th1 and Th2 cells on tumor samples of more than 2,000 patients with colorectal cancer (three independent cohorts). We measured serum levels of Th1 and Th2 cytokines in mesenteric (N = 77) and peripheral (N = 603) blood samples. We evaluated the prognostic significance of Th1 and Th2 cells and their associations with circulating cytokines.
resultsHigh densities of both Th1 and Th2 cells were independently associated with better cancer-specific survival. In the largest cohort, the HR for high vs. low Th1 density was 0.62 (95% confidence interval, 0.44-0.85; PTrend = 0.004) and the HR for high vs. low Th2 density was 0.50 [95% confidence interval, 0.36-0.69; PTrend < 0.001]. Th1 cell density positively correlated with IL12 levels and negatively with IL10 levels in mesenteric serum. Th1:Th2 cell density ratio positively correlated with mesenteric serum Th1:Th2 produced cytokine ratio.
conclusionsThis study supports the prognostic significance of Th1 and Th2 cells in colorectal cancer. Mesenteric serum levels of Th-related cytokines may contribute to or reflect the tumor-associated Th1/Th2 response. IMPACT: Findings highlight comparable roles for Th1 and Th2 cells in predicting favorable outcome and challenge the traditional notion of Th2 cells as tumor promoters.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Significance of Th1 and Th2 Cell Densities and Th1/Th2 Cytokine Profiles in Colorectal Cancer. · full record | OpenQuestion