Evidence map›Paper›PMID 40928289›Full record

ReviewmSphere2025

Dissecting antimicrobial logic: species-specific strategies for intracellular pathogen defense.

Bryan D Bryson

Abstract readReview
In one paragraph

Review in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Bryan D BrysonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0003-1716-6712

Funding

Dynamics of the cellular and molecular architecture of human pulmonary TB granulomasR01AI166313 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROBERT L MODLIN · 2022 to 2026
$3.2M
Type I IFN-dependent and independent contributions to the outcomes of early innate immune cell interactions during HIV/TB co-infectionR01AI184666 · NIAID · WASHINGTON UNIVERSITY · PI Bryan David Bryson, Joshua T. Mattila · 2024 to 2026
$2.6M
High-dimensional characterization of phagosome composition, control and phagocytic receptor redundancyR35GM142900 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI BRYSON, BRYAN DAVID · 2021 to 2025
$2.1M
NIAID NIH HHS R01 AI166313NIAID NIH HHS R01 AI184666NIGMS NIH HHS R35 GM142900NIH HHS R35GM142900, R01AI166313, R01AI184666
6 · The paper itself

Abstract

Control of intracellular pathogens is a critical element of host defense. Defining the molecular mechanisms by which the host restricts or eliminates these pathogens may inform the development of novel immunotherapeutics and antimicrobial strategies, particularly in the face of rising antibiotic resistance. In parallel, understanding how pathogens subvert these immune responses may yield new approaches to disrupt virulence rather than viability. Yet, the precise mechanisms by which primates-and especially humans-achieve intracellular pathogen control remain poorly understood. Five years ago, I reflected on the complexity of interferon-induced control of

Indexed as

Host-Pathogen InteractionsLegionella pneumophilaLegionnaires' DiseaseAnimalsHumansMiceSpecies Specificityhost-pathogen interactionsinnate immunityphagosome

Identifiers

PMID40928289
PMCPMC12482154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.