Evidence map›Paper›PMID 40928249›Full record

ArticleJournal of virology2025

The leader proteins of Theiler's virus and Boone cardiovirus use a combination of short linear motifs (SLiMs) to target RSK kinases to the nuclear pore complex.

Belén Lizcano-Perret, Fanny Wavreil, Martin Veinstein, Camille Duflos, Romane Milcamps, Frédéric Sorgeloos, Thomas Michiels

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Belén Lizcano-Perret *Université catholique de Louvain, de Duve Institute, Brussels, Belgium.ORCID 0000-0002-1962-1689
Fanny Wavreil *Université catholique de Louvain, de Duve Institute, Brussels, Belgium.
Martin VeinsteinUniversité catholique de Louvain, de Duve Institute, Brussels, Belgium.ORCID 0000-0002-0571-5916
Camille DuflosUniversité catholique de Louvain, de Duve Institute, Brussels, Belgium.
Romane MilcampsUniversité catholique de Louvain, de Duve Institute, Brussels, Belgium.ORCID 0009-0001-6934-1298
Frédéric SorgeloosUniversité catholique de Louvain, de Duve Institute, Brussels, Belgium.ORCID 0000-0002-6492-8524
Thomas MichielsUniversité catholique de Louvain, de Duve Institute, Brussels, Belgium.ORCID 0000-0001-9615-8053

Funding

Fonds De La Recherche Scientifique - FNRS AspirantFonds De La Recherche Scientifique - FNRS EOS IDs 30981113 and 40007527Fonds De La Recherche Scientifique - FNRS PDR T.0154.23Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture (FRIA) FellowshipLoterie Nationale (Belgium) support via de Duve Institute
6 · The paper itself

Abstract

Unrelated pathogens, including viruses and bacteria, use a common short linear motif (SLiM) to interact with cellular kinases of the RSK (p90 S6 ribosomal kinase) family. Such a "DDVF" (D/E-D/E-V-F) SLiM occurs in the leader (L) protein encoded by picornaviruses of the genus

Indexed as

CardiovirusNuclear PoreRibosomal Protein S6 Kinases, 90-kDaTheilovirusThogotovirusViral ProteinsAmino Acid MotifsAnimalsHumansPhosphorylationProtein BindingRibosomal Protein S6 Kinases, 90-kDaViral Proteinsboone cardiovirusnuclear pore complexnucleocytoplasmic trafficNUP98ORF6p90 ribosomal S6 kinasepicornavirusRAE1RSKSARS-CoV-2short linear motifSLiMSLiM mimicryTheiler’s murine encephalomyelitits virusTMEV

Identifiers

PMID40928249
PMCPMC12548433

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.