Evidence map›Paper›PMID 40928213›Full record

ArticleeLife2025

Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of fragile X syndrome.

Huei-Bin Wang, Natalie E Smale, Sarah H Brown, Sophia A M B Villanueva, David Zhou, Aly Mulji, Deap S Bhandal, Kyle Nguyen-Ngo, John R Harvey, Cristina A Ghiani and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Huei-Bin WangMolecular, Cellular, Integrative Physiology Graduate Program, University of California, Los Angeles, Los Angeles, United States.
Natalie E SmaleDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, United States.
Sarah H BrownDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, United States.
Sophia A M B VillanuevaDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, United States.
David ZhouDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, United States.ORCID https://orcid.org/0000-0001-6066-3277
Aly MuljiIntegrated Biology and Physiology Program, University of California, Los Angeles, Los Angeles, United States.
Deap S BhandalDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, United States.
Kyle Nguyen-NgoDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, United States.
John R HarveyDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, United States.
Cristina A GhianiDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, United States.ORCID https://orcid.org/0000-0002-9867-6185
Christopher S ColwellDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, United States.ORCID https://orcid.org/0000-0002-1059-184X

Funding

UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peyman Golshani, SUMA JACOB · 2020 to 2026
$9.6M
Eunice Kennedy Shriver National Institute of Child Health and Human Development P50HD103557NICHD NIH HHS P50 HD103557
6 · The paper itself

Abstract

Fragile X syndrome (FXS), a leading inherited cause of intellectual disability and autism, is frequently accompanied by sleep and circadian rhythm disturbances. In this study, we comprehensively characterized these disruptions and evaluated the therapeutic potential of a circadian-based intervention in the fragile X mental retardation 1 (

Indexed as

Behavior, AnimalFragile X SyndromeInflammationAnimalsCircadian RhythmDisease Models, AnimalFragile X Messenger Ribonucleoprotein 1MaleMiceMice, KnockoutFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1circadian rhythmsfragile X syndromeinflammatory cytokinesmouseneurodevelopmental disordersneurosciencescheduled feeding

Identifiers

PMID40928213
PMCPMC12422731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.