Evidence map›Paper›PMID 40928201›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2025

Multiplexed Fluorescent Microarrays on MIL-101(Cr) Thin Films as Luminescent Probes for pH and Disease-Associated Molecules.

Wenjing Wang, Wenwu Yang, Maike Schliephake, Tonghan Zhao, Yan Liu, Navid Hussain, Ben Breitung, Andreas H Schäfer, Pavel A Levkin, Jasmin Aghassi-Hagmann and 2 more

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wenjing WangInstitute of Nanotechnology (INT), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, 76131, Karlsruhe, Germany.ORCID https://orcid.org/0000-0001-6900-1130
Wenwu YangInstitute of Nanotechnology (INT), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, 76131, Karlsruhe, Germany.ORCID https://orcid.org/0000-0003-3985-7098
Maike SchliephakeInstitute of Biological and Chemical Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, 76131, Karlsruhe, Germany.
Tonghan ZhaoInstitute of Microstructure Technology (IMT), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, 76131, Karlsruhe, Germany.ORCID https://orcid.org/0000-0002-5300-1651
Yan LiuInstitute of Nanotechnology (INT), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, 76131, Karlsruhe, Germany.ORCID https://orcid.org/0009-0007-9066-3754
Navid HussainInstitute of Nanotechnology (INT), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, 76131, Karlsruhe, Germany.ORCID https://orcid.org/0000-0002-7662-4245
Ben BreitungInstitute of Nanotechnology (INT), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, 76131, Karlsruhe, Germany.ORCID https://orcid.org/0000-0002-1304-3398
Andreas H SchäfernanoAnalytics GmbH, Heisenbergstraße 11, 48149, Münster, Germany.
Pavel A LevkinInstitute of Biological and Chemical Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, 76131, Karlsruhe, Germany.ORCID https://orcid.org/0000-0002-5975-948X
Jasmin Aghassi-HagmannInstitute of Nanotechnology (INT), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, 76131, Karlsruhe, Germany.ORCID https://orcid.org/0000-0003-0348-041X
Annie K PowellInstitute of Nanotechnology (INT), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, 76131, Karlsruhe, Germany.ORCID https://orcid.org/0000-0003-3944-7427
Michael HirtzInstitute of Nanotechnology (INT), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, 76131, Karlsruhe, Germany.ORCID https://orcid.org/0000-0002-2647-5317

Funding

China Scholarship Council 202009110120China Scholarship Council 202106240010Deutsche Forschungsgemeinschaft EXC2082/1-390761711
6 · The paper itself

Abstract

Recently, metal-organic frameworks (MOFs) have shown high potential in the field of sensing. However, fluorescent-based detection with MOFs in solution needs complex pre-treatments and has stability issues, complicating measurements and handling for sensing applications. Here, an easy-to-handle and low-cost strategy is introduced to convert MOF-based sensing from solution to surface using scanning probe lithography. The MOF is immobilized on the surface by receding meniscus coating, and then fluorescent dyes are patterned on the MOF thin films through microchannel cantilever spotting to generate dye@MOF fluorescent microarrays, which are stable in analyte solutions. The dye@MOF fluorescent microarrays exhibit good pH sensitivity in the pH 5-9 range, and dopamine can be distinguished from three other metabolites in the solution by these microarrays when signals from different dyes are analyzed in combination with principal component analysis. This concept provides a new approach for stable microarray-based detection of small molecule analytes from a fluid environment.

Indexed as

fluorescent chemosensorsmetal‐organic frameworksprincipal component analysisscanning probe lithography

Identifiers

PMID40928201
PMCPMC12571215

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.