Evidence map›Paper›PMID 40928114›Full record

ArticleJournal of periodontal research2025

Multiomics Comparison of Proline-Rich Peptide-Enhanced Hyaluronic Acid Gels Versus Conventional Regenerative Materials: An Early Wound-Healing Model.

Øystein Øvrebø, Ståle Petter Lyngstadaas, Thaqif El Khassawna, Reem Jamous, Qianli Ma, Fernando Muñoz, Maria Permuy, Antonio Gonzalez Cantalapiedra, Antonio José Serrano-Muñoz, Joana Maria Ramis and 3 more

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07581613 (A Novel Proline-rich Peptide Hydrogel for Periodontal Regeneration), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07581613 phase1 / phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Novel Proline-rich Peptide Hydrogel for Periodontal Regeneration: a Multicenter Parallel-arm Randomized Clinical Trial

TypeinterventionalSponsorSiddharth ShanbhagRan2026 to 2030Enrolled40ConditionsPeriodontal Disease, Intrabony Periodontal DefectsArmsHydrogel
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Bone Grafts: Everything You Need to Know.Journal of periodontal research · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Øystein ØvrebøDepartment of Biomaterials, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0001-9170-0202
Ståle Petter LyngstadaasDepartment of Biomaterials, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0002-6361-7644
Thaqif El KhassawnaExperimental Trauma Surgery, Faculty of Medicine, Justus-Liebig University Giessen, Giessen, Germany.ORCID https://orcid.org/0000-0002-1187-8578
Reem JamousExperimental Trauma Surgery, Faculty of Medicine, Justus-Liebig University Giessen, Giessen, Germany.
Qianli MaDepartment of Biomaterials, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0002-7044-8172
Fernando MuñozFacultad de Veterinaria, Universidade de Santiago de Compostela, Lugo, Spain.ORCID https://orcid.org/0000-0002-4130-1526
Maria PermuyFacultad de Veterinaria, Universidade de Santiago de Compostela, Lugo, Spain.ORCID https://orcid.org/0000-0002-3708-4821
Antonio Gonzalez CantalapiedraFacultad de Veterinaria, Universidade de Santiago de Compostela, Lugo, Spain.ORCID https://orcid.org/0000-0002-8586-956X
Antonio José Serrano-MuñozGroup of Cell Therapy and Tissue Engineering, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands, Palma de Mallorca, Spain.ORCID https://orcid.org/0009-0005-7867-8940
Joana Maria RamisGroup of Cell Therapy and Tissue Engineering, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands, Palma de Mallorca, Spain.ORCID https://orcid.org/0000-0001-9109-8362
Marta MonjoGroup of Cell Therapy and Tissue Engineering, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands, Palma de Mallorca, Spain.ORCID https://orcid.org/0000-0002-2731-9527
Filippo RossiDepartment of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Milan, Italy.ORCID https://orcid.org/0000-0003-2665-120X
Håvard J HaugenDepartment of Biomaterials, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0002-6690-7233

Funding

Norges Forskningsråd 327512Norges Forskningsråd 331752Norges Forskningsråd 332148Norway Grants LV-RESEARCH-0005
6 · The paper itself

Abstract

aimsTo compare the early wound-healing responses to crosslinked hyaluronic acid enriched with two proline-rich peptides (P2, P6) against unmodified hyaluronic acid and the enamel-matrix derivative (EMD) in a porcine gingival-detachment model.

methodsIn six pigs, defects around premolars were treated with HA, HA + P2, HA + P6 or EMD. After 6 days, the sites were harvested and evaluated using histology, immunohistochemistry, multiplex cytokine assay and untargeted proteomics of the gels, which were examined, informing an integrated multiomics approach analysis.

resultsBoth peptide formulations improved the composite histological score compared to HA alone, and HA + P6 matched EMD in suppressing oedema, TNF-α staining and CD80

conclusionHA + P6 suppressed TNF-α and trypsin signalling while boosting M2-linked markers and proresolution proteins to the same extent as EMD, whereas plain HA did not. Thus, adding a short proline-rich peptide confers EMD-like early immunomodulation on a fully synthetic HA carrier. These observations, although limited to 6-day soft tissue healing, warrant longer studies in true periodontal regeneration models.

Indexed as

Hyaluronic AcidPeptidesProlineWound HealingAnimalsDental Enamel ProteinsDisease Models, AnimalGelsGingivaMultiomicsProteomicsSwineTumor Necrosis Factor-alphaDental Enamel Proteinsenamel matrix proteinsGelsHyaluronic AcidPeptidesProlineTumor Necrosis Factor-alphaenamel‐matrix derivativegingival regenerationhyaluronic acidimmunomodulationmultiomicsporcine modelproline‐rich peptideproteomics

Identifiers

PMID40928114
PMCPMC12640218

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.