ArticleCNS neuroscience & therapeutics2025
Deer Antler S-Adenosylmethionine Ameliorates Depression-Like Behaviors and Neuroinflammation in CUMS Mice.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Deer Antler S-Adenosylmethionine Ameliorates Depression-Like Behaviors and Neuroinflammation in CUMS Mice.CNS neuroscience & therapeutics · 2025Article
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9 authors.
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Abstract
aimTo investigate the effects and mechanisms of S-adenosylmethionine (SAM) from deer antler on improving depression-like behaviors in chronic unpredictable mild stress (CUMS) mice.
methodsThe CUMS method was used to establish a mouse depression model. The relationship between SAM and HIF-1α was analyzed by small molecule-protein docking and molecular dynamics simulation.
resultsNetwork pharmacology analysis showed that the effect of SAM is related to HIF-1α. When shRNA-HIF-1α was used to silence the expression of HIF-1α, the effect of SAM was inhibited. The improvement of depression-like behaviors in mice was not significant, and inflammatory factors were no longer further downregulated.
conclusionSAM can improve depression-like behaviors in CUMS mice and enhance their mobility. SAM inhibits neuroinflammation and glycolysis, and also suppresses the activation of microglia.
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