Evidence map›Paper›PMID 40927827›Full record

ArticleInternal medicine journal2025

Temporal trends in gender-affirming hormone therapy initiation: evidence from whole-of-population Australian administrative data.

Karinna Saxby, Brendan J Nolan

Abstract read
In one paragraph

Article in Internal medicine journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Cardiometabolic diseases in transgender populations.Cardiovascular diabetology. Endocrinology reports · 2026
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Karinna SaxbyApplied Economic and Social Research, Faculty of Business and Economics, Melbourne Institute, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-0100-8437
Brendan J NolanTrans Health Research Group, Medicine (Austin Health), University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0001-8836-165X

Funding

National Health and Medical Research Council 2034450University of Melbourne McKenzie Fellowship 2025MCK182Viertel Charitable Foundation Clinical Investigator Award
6 · The paper itself

Abstract

Using longitudinal national prescribing data, we estimated the number of transgender and gender-diverse individuals initiating gender-affirming hormone therapy (GAHT) from 2013 to 2024 in Australia. Between 2013 and 2024, 11 883 individuals initiated testosterone-based GAHT and 20 358 initiated oestrogen-based GAHT. Initiation rose from 1118 in 2013 to 5135 in 2024, with a growing share accessing testosterone-based GAHT over time. The mean age at initiation also fell from 50 years in 2013 to 26 years in 2024. Our findings align with international trends, suggesting increasing demand among younger populations. This highlights the need for specialised, accessible gender-affirming care in Australia and underscores the importance of improved data collection to inform health policy and clinical practice.

Indexed as

EstrogensHormone Replacement TherapyTestosteroneTransgender PersonsAdolescentAdultAustraliaFemaleHumansLongitudinal StudiesMaleMiddle AgedYoung AdultEstrogensTestosteronegender‐affirming hormone therapygender diversetransgender

Identifiers

PMID40927827
PMCPMC12704399

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.