Evidence map›Paper›PMID 40927825›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2025

Parasagittal dural space and arachnoid granulations morphology in pre-clinical and early clinical multiple sclerosis.

Ahmad Toubasi, Kilian Hett, Junzhong Xu, Caroline Gheen, Taegan Vinarsky, Chloe Cho, James E Eaton, Shailee Shah, Colin McKnight, Richard D Dortch and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ahmad ToubasiNeuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-4688-9728
Kilian HettCognitive Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Junzhong XuVanderbilt University Institute of Imaging Sciences, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Caroline GheenNeuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Taegan VinarskyNeuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Chloe ChoVanderbilt University School of Medicine, Nashville, TN, USA.ORCID 0000-0001-5114-001X
James E EatonCognitive Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Shailee ShahNeuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-3451-0303
Colin McKnightDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-4386-8999
Richard D DortchDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, USA.
Manus J DonahueCognitive Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Psychiatry and Behavioral Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Francesca BagnatoNeuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, VA Medical Center, TN Valley Healthcare System, Nashville, TN, USA.ORCID 0000-0001-9544-9019

Funding

CSRD VA I01 CX002160
6 · The paper itself

Abstract

backgroundThere is limited knowledge on the post-glymphatic structures such as the parasagittal dural (PSD) space and the arachnoid granulations (AGs) in multiple sclerosis (MS).

objectivesTo evaluate differences in volume and macromolecular content of PSD and AG between people with newly diagnosed MS (pwMS), clinically isolated syndrome (pwCIS), or radiologically isolated syndrome (pwRIS) and healthy controls (HCs) and their associations with clinical and radiological disease measures.

methodsA total of 69 pwMS, pwCIS, pwRIS, and HCs underwent a 3.0 Tesla magnetic resonance imaging (MRI) including selective inversion recovery quantitative magnetization transfer imaging to compute the macromolecular-to-free water pool-size-ratio (PSR) and the free water relaxation rate (R

resultsAfter adjusting for age and sex, larger frontal (

conclusionUpon diagnosis, enlarged structures in the post-glymphatic system may be observed, indicating a need for further investigation of their role.

Indexed as

ArachnoidDemyelinating DiseasesDura MaterMultiple SclerosisAdultFemaleGlymphatic SystemHumansMagnetic Resonance ImagingMaleMiddle AgedYoung Adultarachnoid granulationsmultiple sclerosisparasagittal dural spacePost-glymphatic system

Identifiers

PMID40927825
PMCPMC12501394

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.