Evidence map›Paper›PMID 40927751›Full record

ArticleInternational journal of pharmaceutics: X2025

Ultra-sensitive pH responsive hydrogels with injectable and self-healing performance for controlled drug delivery.

Yang Yu, Yili Zhao, Yujiao Zou, Chanyi Lu, Ni Li, Zhiyuan Shi, Xin Li, Xixi Lai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. Functional Dendrimer Nanogels for DNA Delivery and Gene Therapy of Tumors.Angewandte Chemie (International ed. in English) · 2025
    Article
  17. Article
  18. Article
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  20. A Review of Silica-Based Nanoplatforms for Anticancer Cargo Delivery.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yang YuDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China.
Yili ZhaoState Key Laboratory of Bio-based Fiber Materials, College of Textile Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Yujiao ZouState Key Laboratory of Bio-based Fiber Materials, College of Textile Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Chanyi LuState Key Laboratory of Bio-based Fiber Materials, College of Textile Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Ni LiState Key Laboratory of Bio-based Fiber Materials, College of Textile Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Zhiyuan ShiTianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
Xin LiDepartment of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Hong Kong 999077, China.
Xixi LaiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultra-sensitive pH-responsive drug delivery system designed to operate within the slightly acidic microenvironment of tumors are highly desired for hydrogel applications in cancer therapy. In this study, 4-Formylbenzoic acid modified polyvinyl alcohol (PVA-FBA, PF) was synthesized and utilized as a carrier for encapsulating the anticancer drug Doxorubicin (Dox). This was subsequently crosslinked with polyethylenimine (PEI) via benzoic-imine bond to form drug-loaded PVA-FBA/PEI hydrogel (D-PFP). The D-PFP hydrogel was characterized using various techniques. The results indicated that the optimal conditions for hydrogel preparation involved using PF-0.25 polymer, which had an aldehyde group content of 0.82 mmol/g, as the precursor, along with a 12 wt% precursor solution for crosslinking with a 5 wt% PEI solution. The resulting hydrogel exhibited good structural stability and favorable morphology. Drug release studies indicated that the hydrogel demonstrated minimal drug leakage under physiological conditions (pH 7.4), while exhibiting a significantly higher drug release rate at pH 6.8, thereby underscoring its superior pH sensitivity. Rheological evaluations further confirmed its injectability and self-healing properties. Moreover, the hydrogel displayed excellent cytocompatibility and significantly inhibited cancer cell activity at pH 6.8. These characteristics suggest the potential of this hydrogel as a drug delivery system with ultra-sensitive drug release properties, particularly for future applications in chemotherapy for cancer.

Indexed as

HydrogelInjectableSchiff-baseSelf-healingUltra pH-sensitive drug release

Identifiers

PMID40927751
PMCPMC12416092

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.