ArticleiScience2025
Neural dynamics of proactive and reactive cognitive control in medial and lateral prefrontal cortex.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Insights into the neural mechanisms supporting cognitive stability and flexibility from human intracranial electroencephalography.Neuroscience and biobehavioral reviews · 2026Review
- Adaptive behavior is guided by integrated representations of controlled and non-controlled information.eLife · 2026Article
- Distinct neural oscillations predict individual differences in feedback-guided cognitive flexibility.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Nonlinear and intensity-dependent enhancement of sweetness perception as a function of redness: Behavioral and EEG evidence for visual-gustatory cross-modal integration.Food chemistry: X · 2026Article
- Designing Neural Dynamics: From Digital Twin Modeling to Regeneration.International journal of molecular sciences · 2025Review
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Authors and funding
10 authors.
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Abstract
Goal-directed behavior requires adjusting cognitive control, both in preparation for and in reaction to conflict. Theta oscillations and population activity in dorsomedial prefrontal cortex (dmPFC) and dorsolateral PFC (dlPFC) are known to support reactive control. Here, we investigated their role in proactive control using human intracranial electroencephalogram (EEG) recordings during a Stroop task that manipulated conflict expectations. During response selection, conflict processing enhanced dlPFC beta desynchronization, dmPFC theta increases, and high-frequency activity (HFA, which indexes local population activity) in both regions. After responses, conflict suppressed theta and boosted beta rebounds in both regions. Importantly, pre-trial dmPFC theta increased when conflict was anticipated, and within-trial theta, beta, and HFA dynamics were accentuated when conflict was rare. These findings reveal how the balance of reactive and proactive control modulates shared HFA and dissociable theta-beta conflict signals in dmPFC and dlPFC and identifies pre-trial dmPFC theta as a candidate substrate for proactive control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.