ArticleBiochemistry and biophysics reports2025
5-HMF plays an intervention role in ischemic stroke by regulating GluR2 to improve mitochondrial function and promote angiogenesis.
Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: 5-Hydroxymethyl furfural (5-HMF) is a furan compound with a molecular formula of C Methods: The MCAO animal model was used to detect the related indexes of behavior, neurological function and mitochondrial function, and to clarify the effect of 5-HMF on ischemic stroke. The HBMECs model induced by OGD-R was intervened by 5-HMF, and the GluR2 silencing sequence was added to detect mitochondrial function and angiogenesis-related indicators, so as to further explore the mechanism of 5-HMF intervention in ischemic stroke. Results: In the MCAO experiment, the behavioral results showed that 5-HMF increased the quantity of autonomic activities, increased the exercise time and distance, reduced the balance beam score, and prolonged the residence time of MCAO rats on the rotating rod ( Conclusions: 5-HMF has the effect of ameliorating brain damage in MCAO rats, and by regulating the expression of GluR2, reducing intracellular Ca
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